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Method and device for measuring blood information

A blood information and measurement method technology, applied in the field of blood information measurement, can solve problems such as unreliability, and achieve the effects of easy measurement and stable distribution orientation

Inactive Publication Date: 2014-11-05
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In particular, hemoglobin monitoring in dialysis is an important indicator for observing water removal efficiency, but the current continuous hemoglobin monitor is not reliable enough

Method used

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  • Method and device for measuring blood information
  • Method and device for measuring blood information
  • Method and device for measuring blood information

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Experimental program
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Embodiment Construction

[0072] Embodiments of the present invention will be described in detail below with reference to the drawings.

[0073] The first embodiment of the present invention, such as Image 6 As shown, there is provided: a flow cell 40, which is formed into a square tubular cross-section, a glass tube 42 constituting a blood flow path, and a trapezoidal glass tube 42 fixed to one side wall of the glass tube 42 (the lower side wall in the figure). Container 44, the liquid paraffin 46 that is filled in this glass container 44 constitutes; White light source 50; Inclined surface) 44A is incident as the first measurement light (incident light) 30 via collimating lens 54; Light-receiving optical fiber 58 is used for detecting the regular reflection at the boundary surface of blood 10 and glass tube 42, passing through collimating lens 56 from above-mentioned glass container 44 The reflected light 32 emitted by another inclined plane (the inclined plane on the right side in the figure) 44B;...

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Abstract

Blood information such as hemolysis (a plasma-free hemoglobin concentration) and a blood coagulation level (thrombus) can be obtained by extracting only reflected light in a plasma layer, and non-invasively and continuously obtaining information only on a plasma component independently of a hematocrit without separating blood components by a mechanical or chemical process. First measurement light 30 is caused to be incident on a boundary surface between blood 10 flowing through a flow cell 40 formed of a transparent material having a different refractive index from plasma (layer) 12 in the blood 10 and the flow cell 40, from an oblique direction at an angle smaller than 90 degrees. Reflected light 32 regularly reflected at the boundary surface between the flow cell 40 and the blood 10 is subjected to spectrometry. Information on a plasma component (a refractive index Np of plasma) is obtained from an absorption spectrum measured.

Description

technical field [0001] The present invention relates to a measurement method and a measurement device for blood information, and in particular, relates to the ability to continuously obtain information on only plasma components independently of hematocrit without invasiveness, and to measure hemolysis (plasma free hemoglobin concentration), blood coagulation degree (thrombosis) and other blood information methods and devices. Background technique [0002] It is desirable to non-invasively and continuously measure the degree of hemolysis and blood coagulation of blood exported outside the body through an artificial circulatory channel. In particular, the hemoglobin monitoring in dialysis is more important as an indicator to observe the water removal efficiency, but the current continuous hemoglobin monitor is not reliable enough. [0003] In addition, there is a risk of blood coagulation in all blood circulatory system equipment, and continuous monitoring of anticoagulant dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/27
CPCG01N21/05G01N21/552G01N21/31G01N2021/1736G01N2021/8405G01N33/49A61B5/1455
Inventor 迫田大辅高谷节雄
Owner NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV
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