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Echinacea extract product, preparation method and application thereof

A technology of Echinacea purpurea extract and Echinacea purpurea, applied in the direction of medical formula, drug combination, plant raw materials, etc., can solve the problems of damage to cichoric acid and other components, large ethanol consumption, low production efficiency, etc., and achieve the promotion of mouse hemolysin antibody production , High transfer rate of active ingredients, easy quality control effect

Active Publication Date: 2014-11-05
QINGDAO KDN BIOTECH +1
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Problems solved by technology

It has the following disadvantages: ①The extract is directly subjected to microfiltration treatment, which may easily cause clogging of the microfiltration membrane, and the production efficiency is low, so it is not suitable for large-scale production
This method has the following deficiencies: ① The preparation process takes fresh Echinacea purpurea as the research object. Although the content of cichoric acid in fresh Echinacea purpurea is relatively high, the production of Echinacea purpurea extract is limited by seasons, and the source of medicine of Echinacea purpurea extract limits its industrialization Production
②The production process is mainly based on the content of cichoric acid, and the polysaccharide components that play an immune role in the medicinal materials are not considered, resulting in a waste of medicinal material resources to a certain extent
③In the preparation process, the medicinal materials are extracted twice with high-concentration ethanol, and a large amount of ethanol is adsorbed in the dregs of the medicine, but no treatment has been seen, and the cost of the Echinacea purpurea extract produced by it is relatively high
[0007] CN200610061847.6 (publication number is CN101032541A) discloses a kind of Echinacea purpurea extract and its preparation method and content determination method, and this method has the following deficiencies: 1. The amount of ethanol used for extraction is large, the ethanol consumption is large, and the cost is high
According to experimental research, the transfer rate of chicory acid in the process is low, about 40-50%
②The content of cichoric acid in the Echinacea purpurea extract prepared by its process is low, and the index is single, which does not reflect the content transfer of total polyphenols and total polysaccharides
It has the following disadvantages: extraction with pH=12 calcium hydroxide ethanol solution is likely to cause calcium ions to chelate with polyphenolic components such as cichoric acid to form precipitated insoluble matter, and it is easy to cause cichoric acid to contain esters in a high-temperature alkaline environment. The breakage of bonds causes the destruction of components such as cichoric acid, but in fact, through the alkali-alcohol extraction method of this document, its content cannot reach the content limited by this document
[0011] At present, most of the commercially available Echinacea purpurea extracts are based on the content of total phenols and cichoric acid. Most of them are yellow-green powders, and the price is relatively high. It has been determined that the polysaccharides contained in them are relatively low, less than 5%, and there is no label on the market. Echinacea Extract of Echinacea Polysaccharide Content

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  • Echinacea extract product, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: the extraction method of Echinacea purpurea

[0057] 1. Echinacea purpurea, crushed, passed through a 15-mesh sieve, and set aside;

[0058] 2. Take the Chinese herbal medicine powder in step 1, add a 70% ethanol solution containing 0.2% citric acid in a volume 8 times the weight of Echinacea purpurea powder, reflux extraction for 2.0 hours, filter to obtain the filtrate and medicinal residues, and concentrate the filtrate to 60°C under reduced pressure Measure the extract whose relative density is 1.12, for subsequent use;

[0059] 3. Add the dregs obtained in step 2, add 0.1% sodium carbonate solution of 6 times the weight of Echinacea powder, extract by warm soaking at 75°C for 1.0 hour, filter to obtain the filtrate and dregs, discard the dregs, and concentrate the filtrate under reduced pressure Measure the extract with a relative density of 1.08 at 60°C and set aside;

[0060] 4. Combine the extracts obtained in step 2 and step 3, perform high-spee...

Embodiment 2

[0061] Embodiment 2: the extraction method of Echinacea purpurea

[0062] 1. Take 10kg of Echinacea purpurea roots, crush them, pass through a 15-mesh sieve, and set aside;

[0063] 2. Take the Chinese herbal medicine powder in step 1, add a 75% ethanol solution containing 0.3% hydrochloric acid in a volume 7 times the weight of Echinacea purpurea powder, reflux extraction for 1.5 hours, filter to obtain the filtrate and medicinal residues, and concentrate the filtrate under reduced pressure to 60°C for measurement The extract whose relative density is 1.07 is for subsequent use;

[0064] 3. With the dregs obtained in step 2, add 0.15% sodium bicarbonate solution of 6 times the volume of echinacea powder weight, extract by warm soaking at 80°C for 40 minutes, filter to obtain the filtrate and dregs, discard the dregs, and remove the dregs from the filtrate. Concentrate under pressure to 60 ° C to measure the extract whose relative density is 1.08, and set aside;

[0065] 4. ...

Embodiment 3

[0067] Embodiment 3: the extraction method of Echinacea purpurea

[0068] 1. Take 10kg of the whole plant of Echinacea purpurea, crush it, pass through a 24-mesh sieve, and set aside;

[0069] 2. Take the Chinese medicinal material powder in step 1, add 8 times the amount of 60% ethanol solution containing 0.3% acetic acid, reflux extraction for 2.0 hours, and filter to obtain the filtrate and medicinal residues. The filtrate is concentrated under reduced pressure to 60 ° C and the relative density is 1.08. Extract, spare;

[0070] 3. Add 7 times the amount of 0.05% sodium hydroxide solution to the dregs obtained in step 2, soak and extract at 70°C for 1.0 hour, filter to obtain the filtrate and dregs, discard the dregs, and concentrate the filtrate to 60°C under reduced pressure Measure the extract whose relative density is 1.08, for subsequent use;

[0071] 4. Combine the extracts obtained in step 2 and step 3, and perform high-speed tubular centrifugation to obtain the cl...

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Abstract

The invention relates to an echinacea extract product, a preparation method and an application, the extract product comprises the following components by weight percentage: content of phenolic compounds is higher than 12%, content of Echinacea polysaccharide is higher than 20%, and chicoric acid content is higher than 4%. The extract product has obvious promotion effect to the generation of mice hemolysin antibody, the echinacea extract product can enhance humoral immunity, and the effect of the echinacea extract product is better than that of the prior art.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to an extract of Echinacea purpurea and its preparation method and application. Background technique [0002] Echinacea (Echinacea) is a kind of echinacea plant native to North America and southern Canada. There are 8 species and several varieties in this genus. At present, there are mainly three varieties developed as medicines. Purple coneflower (Echinacea purpurea, commonly known as Echinacea), Echinacea augustifolia, and Echinacea pallida. [0003] Echinacea purpurea is an immunostimulant and immunomodulator that is widely valued internationally. It is a world-renowned "immune" herbal medicine with outstanding anti-infection and immune-promoting effects. Its extracts and preparations rank first in the sales of American herbal medicines. Ranked top 5 in terms of market sales, it has received great attention both at home and abroad. [0004] At present, the extraction of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P37/04A61P31/00A61P29/00
Inventor 钟英杰蒋贻海付海宁张会梅庞云露贺倩倩
Owner QINGDAO KDN BIOTECH
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