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A kind of surface functionalized micro-nano polymer gel particle and preparation method thereof

A surface functionalization and polymer technology, applied in the field of new materials, can solve the problems of complex preparation process of micro-nanoparticles, weak functional group reactivity, single functional group, etc., to achieve uniform particle size, broad application value, polymerization simple craftsmanship

Inactive Publication Date: 2016-06-15
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These materials have their own characteristics and can be modified to a certain extent, but the reactivity of the functional groups is not strong, and the functional groups are relatively single, and specific follow-up reactions are required to meet the actual application requirements. The preparation process of micro-nanoparticles as ingredients is relatively complicated

Method used

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  • A kind of surface functionalized micro-nano polymer gel particle and preparation method thereof
  • A kind of surface functionalized micro-nano polymer gel particle and preparation method thereof
  • A kind of surface functionalized micro-nano polymer gel particle and preparation method thereof

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preparation example Construction

[0059] The preparation method of micro-nano polymer gel particles: Feed the reaction monomer, polymerization initiator, and solvent into the reactor equipped with nitrogen conduit, condenser, stirrer, and thermometer at one time according to the set ratio, fully dissolve and mix evenly ; Nitrogen and oxygen exhaust for 15-30min; heat the solution system in a constant temperature water bath, the temperature is 45-120°C, the time is 5-600min, the stirring rate is 0-450rpm; after the reaction is completed, the obtained product is separated by a high-speed centrifuge, The rotation speed is 5000-12000rpm; the centrifuged product is washed with a solvent, centrifuged and washed again, and repeated 3-5 times; the final centrifuged product is placed in a vacuum oven and dried at 60°C until it reaches a constant weight.

[0060] Wherein, the reactive monomer includes: methylene succinic anhydride, N-vinylpyrrolidone, and a crosslinking agent. Preferably, the reactive monomer consists o...

Embodiment 1

[0079] Methylene succinic anhydride 0.65g, N-vinylpyrrolidone 0.25g, divinylbenzene 0.3g, dibenzoyl peroxide 0.01g, butyl acetate 72mL, cyclohexanone 12mL, n-hexane 15mL, add to 250mL Fully dissolve in a three-necked flask; pass nitrogen and oxygen for 20 minutes; heat the solution system in a constant temperature water bath to initiate polymerization reaction, keep the temperature at 85°C, and complete the reaction for 8 hours. The product was separated with a centrifuge at 5000 rpm, washed with butyl acetate, centrifuged again and washed three times; the final centrifuged product was placed in a vacuum oven and dried at 60°C until it reached a constant weight.

[0080] The transmission electron micrograph of gained micronano polymer gel particle sees figure 1 . The average particle diameter of the particles is 76nm, and the particle size distribution index is 1.05, which is close to monodispersity.

Embodiment 2

[0082] Other conditions were the same as in Example 1, except that the amounts of methylene succinic anhydride, N-vinylpyrrolidone, and divinylbenzene were 1.5 g, 0.8 g, and 1.2 g, respectively.

[0083] The transmission electron micrograph of gained micronano polymer gel particle sees figure 2 . The average particle size of the particles is 115nm, and the particle size distribution index is 1.03, which is close to monodispersity, indicating that the particle size of the polymer gel particles increases with the increase of the monomer concentration.

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Abstract

The invention discloses a polymer gel particle, and particularly discloses a surface-functionalized micro-nano polymer gel particle and a preparation method thereof. A chemical structure of the polymer gel particle simultaneously contains an anhydride group and a pyrrolidone group which are connected into a cross-linked structure through a cross-linking agent. The polymer gel particle is prepared by reacting itaconic anhydride, N-vinylpyrrolidone and the cross-linking agent, the ratio of which is (2-4) to (1-2) to (1-2), preferably, (2-3) to (1-1.5) to (1-1.5). The surface-functionalized micro-nano polymer gel particle can be used in the biomedicine fields of drug carriers, targeted preparations, cancer diagnosis, hepatitis detection, protein separation, cell separation, immunoabsorption and the like.

Description

technical field [0001] The invention belongs to the field of new materials, and relates to a polymer gel particle, in particular to a surface-functionalized micro-nano polymer gel particle and a preparation method thereof. Background technique [0002] Polymer micro-nanoparticles have the characteristics of large specific surface area, strong adsorption, strong agglutination, and strong surface reaction ability. They are widely used in the fields of medicine and biochemistry. They can be used in clinical testing, drug delivery, and diagnosis of cancer and hepatitis. , cell labeling, identification, isolation and culture, radioimmunosolid phase carrier and immune absorption, etc. [0003] Targeted drugs can selectively reach specific diseased tissues of the human body and slowly release active ingredients in order to maximize the efficacy of the drug, while reducing the side effects of the drug system and reducing the number of administrations. Therefore, targeted drug delive...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/04C08F226/10C08F212/36C08F290/06
Inventor 李楠邢长民王雪明张萌张林翟俊山李娜朱建华
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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