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Composite gel containing traditional Chinese medicine composition and calcium ion and preparation method thereof

A composite gel and composition technology, which is applied in the directions of drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of limited anti-adhesion effect, aggravated adhesion, etc., and achieves simple formula and good biocompatibility. , Significant anti-adhesion effect

Active Publication Date: 2014-10-29
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this anti-adhesion effect is limited, and when there is injury or infection in the adhesion-prone area, it will aggravate the adhesion in this area

Method used

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  • Composite gel containing traditional Chinese medicine composition and calcium ion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0057] A composite gel containing traditional Chinese medicine composition and calcium ions for preventing postoperative adhesion, the weight percentage composition is as follows:

[0058] Chinese medicine composition 10%， hyaluronic acid 38%， Erythromycin 7.6% Hydrocortisone 0.21%， CaCl2 0.18%， Tranister 9.5%， Deionized water margin;

[0059] The preparation method is:

[0060] (1), dissolving hyaluronic acid in deionized water to obtain 20wt% hyaluronic acid solution A;

[0061] (2), 5wt% CaCl2 solution is added dropwise in hyaluronic acid solution A, while stirring, so that the two are fully mixed to obtain mixed gel B, the volume ratio of CaCl2 solution and hyaluronic acid solution A is 20:100, adjust The pH value is 7;

[0062] (3), B is freeze-dried by a lyophilizer, and pressed into powder C;

[0063] (4) The traditional Chinese medicine composition Ligusticum chuanxiong, Salvia miltiorrhiza, and dried blood are crus...

Embodiment 3

[0068] A composite gel containing traditional Chinese medicine composition and calcium ions for preventing postoperative adhesion, the weight percentage composition is as follows:

[0069] Chinese medicine composition 15%， Chitosan 35%， Erythromycin 5.6% Hydrocortisone 0.19%， CaCl2 0.21%， Tranister 11.6%， Deionized water margin;

[0070] The preparation method is:

[0071] (1), chitosan is dissolved in deionized water to obtain 15wt% chitosan solution A;

[0072] (2), 6wt%CaCl solution is added dropwise in chitosan solution A, while stirring, the two are fully mixed to obtain mixed gel B, CaCl The volume ratio of solution and chitosan solution A is 5: 100, adjust The pH value is 7;

[0073] (3) The traditional Chinese medicine composition Ligusticum chuanxiong, Salvia miltiorrhiza, and dried blood were pulverized, sieved at a ratio of 3:2:1, and cyclodextrin was added to make clathrate D;

[0074] (4), after mixing the gel ...

Embodiment 4

[0077] A composite gel containing traditional Chinese medicine composition and calcium ions for preventing postoperative adhesion, the weight percentage composition is as follows:

[0078] Chinese medicine composition 11%， hyaluronic acid 46%， streptomycin and tetracycline 8.4% Prednisone 0.12%， CaCl2 0.23%， Tranister 8.0%， Deionized water margin;

[0079] The preparation method is:

[0080] (1), dissolving hyaluronic acid in deionized water to obtain 12wt% hyaluronic acid solution A;

[0081] (2), 0.1wt% CaCl2 solution is added dropwise in hyaluronic acid solution A, while stirring, the two are fully mixed to obtain mixed gel B, the volume ratio of CaCl2 solution and hyaluronic acid solution A is 20:100, Adjust the pH value to 7;

[0082] (3), B is dried at high temperature or air-dried, and then pressed into powder C;

[0083] (4) The traditional Chinese medicine composition Ligusticum chuanxiong, Salvia miltiorrhiza, and...

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Abstract

The invention relates to a composite gel containing a traditional Chinese medicine composition and calcium ion and a preparation method thereof. The composite gel containing the traditional Chinese medicine composition and calcium ion is composed of the following substances in percent by weight: 10-18% of the traditional Chinese medicine composition, 30-50% of hyaluronic acid or chitosan, 1.2-10.5% of a salt-resistant medicine, 0.03-0.5% of a hormone medicine, 0.15-0.25% of CaCl2, 5.0-15.0% of tranilast and the balance deionized water. The traditional Chinese medicine composition is obtained though clathration of ligusticum wallichii, radix salviae miltiorrhizae and sanguis draxonis by cyclodextrin. The composite gel containing the traditional Chinese medicine composition and calcium ion has relatively good postoperative antistick effect.

Description

technical field [0001] The invention relates to a postoperative anti-adhesion gel and a preparation method thereof, in particular to a composite gel containing a traditional Chinese medicine composition and calcium ions and a postoperative anti-adhesion gel and a preparation method thereof. Background technique [0002] Postoperative adhesion is not only a common clinical phenomenon in the field of surgery, but also a pathophysiological process that must occur during the surgical healing process. As a common clinical phenomenon, postoperative adhesions can lead to serious clinical complications, such as intestinal obstruction, abdominal and pelvic pain, infertility, etc., increasing the difficulty of reoperation and the potential risk of further complications. [0003] The purpose of preventing adhesions is to eliminate or reduce the severity and scope of adhesions, thereby preventing the occurrence of complications caused by adhesions. At present, although the anti-adhesio...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K9/00A61K36/889A61K36/896A61P41/00A61K31/196
Inventor 姚文健白玉刘小红董鑫张哲莹
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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