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Cefradine composition

A cefradine and drug technology, applied in the field of cefradine combination medicine and its preparation, can solve the problems of increased product storage cost and transportation cost, inconvenient storage and transportation, unstable storage, etc., and achieves protection of liver tissue and cells, safe use, A stable effect

Inactive Publication Date: 2014-10-22
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, because cephradine for injection is not stable when stored in the greenhouse, it is easily damaged when exposed to external forces such as light, heat, water, oxidation, etc., which brings great inconvenience to storage and transportation, and also increases product storage costs and transportation. cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Invented a combination medicine of cefradine, which is made of the following effective medicinal ingredients in parts by weight:

[0025] Cefradine 60

[0026] Borneol 2

[0027] Vitamin E 6

[0028] Sodium carbonate 3

[0029] The method of cefradine combination medicine, its preparation method and steps are as follows:

[0030] (1) Take water for injection with a weight of 5-15 times the weight of the cefradine, and dissolve the cefradine, borneol, vitamin E, and sodium carbonate completely under stirring to obtain a combined drug solution of cefradine.

[0031] (2) Use an ultrafiltration membrane with a molecular weight cut-off of 4000D to obtain the drug solution in step (1). The filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D. The filtrate is adjusted to pH 6.5-7.6 with 8% sodium hydroxide solution;

[0032] (3). The medicinal solution obtained in step (2) is steam sterilized at 121°C for 20 minutes;

[0033] (4). When the sterilized med...

Embodiment 2

[0038] Invented a combination medicine of cefradine, which is made of the following effective medicinal ingredients in parts by weight:

[0039] Cefradine 75

[0040] Borneol 6

[0041] Vitamin E 9

[0042] Sodium carbonate 5

[0043] The method of cefradine combination medicine, its preparation method and steps are as follows:

[0044] (1) Take water for injection with a weight of 5-15 times the weight of the cefradine, and under stirring, dissolve the cefradine, borneol, vitamin E, and sodium carbonate completely to obtain a combined drug solution of cefradine;

[0045] (2) Use an ultrafiltration membrane with a molecular weight cut-off of 4000D to obtain the drug solution in step (1). The filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D. The filtrate is adjusted to pH 6.5-7.6 with 8% sodium hydroxide solution;

[0046] (3). The medicinal solution obtained in step (2) is steam sterilized at 121°C for 20 minutes;

[0047] (4). When the sterilized m...

Embodiment 3

[0052] Invented a combination medicine of cefradine, which is made of the following effective medicinal ingredients in parts by weight:

[0053] Cefradine 103

[0054] Borneol 9

[0055] Vitamin E 13

[0056] Sodium carbonate 8

[0057] The method of cefradine combination medicine, its preparation method and steps are as follows:

[0058] (1) Take water for injection with a weight of 5-15 times the weight of the cefradine, and under stirring, dissolve the cefradine, borneol, vitamin E, and sodium carbonate completely to obtain a combined drug solution of cefradine;

[0059] (2) Use an ultrafiltration membrane with a molecular weight cut-off of 4000D to obtain the drug solution in step (1). The filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 2000D. The filtrate is adjusted to pH 6.5-7.6 with 8% sodium hydroxide solution;

[0060] (3). The medicinal solution obtained in step (2) is steam sterilized at 121°C for 20 minutes;

[0061] (4). When the sterilized...

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Abstract

The invention provides a cefradine composition. The cefradine composition is prepared by using cefradine, borneol, vitamin E and sodium carbonate according to a weight part ratio of 60-140:2-14:6-20:3-12. The invention also provides a preparation method of the composition. The cefradine composition is better than cefradine compositions in the prior art in safety, stability and curative effects, and the preparation method of the cefradine composition has the advantages of energy saving and environmental protection.

Description

Technical field [0001] The invention relates to a combination medicine of cefradine and a preparation method thereof. Background technique [0002] Cefradine (Cephradine, Velosef) Alias: cephalosporin VI, cephalosporin VI, etc. This product is the first-generation semi-synthetic cephalosporin, and its antibacterial effect is similar to that of cephalexin. This product is acid-resistant and can be taken orally with good absorption and high blood concentration. It is characterized by β-lactamase resistance, rapid and reliable bactericidal action against drug-resistant Staphylococcus aureus and other bacilli resistant to broad-spectrum antibiotics. , Mainly excreted in the urine in its original form, with a higher concentration in urine. Clinically, it is mainly used for infections of the respiratory tract, urinary tract, skin and soft tissues, such as bronchitis, pneumonia, pyelonephritis, cystitis, ear, nose, and throat infections, enteritis, and dysentery. At present, because ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/545A61K47/10A61K47/22A61K47/04A61P31/04
Inventor 邓学峰
Owner 邓学峰
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