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Method for extracting rutin from Japanese pagoda tree flowers

A technology of sophora japonica and rutin is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., to achieve the effects of shortening crystallization time, easy operation and improving extraction efficiency.

Active Publication Date: 2014-10-15
内蒙古昶辉生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are reports on the use of surfactants to assist the extraction of rutin, but more than one surfactant is used

Method used

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  • Method for extracting rutin from Japanese pagoda tree flowers
  • Method for extracting rutin from Japanese pagoda tree flowers
  • Method for extracting rutin from Japanese pagoda tree flowers

Examples

Experimental program
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Effect test

Embodiment 1

[0018] 50g of dried Sophora japonica was treated by dry steaming at 70°C for 30min, then rinsed with hot water at 70°C to remove the gelatin, then dried in the air and crushed into 20 meshes. Add 3% borax and 1% Na to Sophora japonica granules 2 SO 3 and 20 times of 60-70% ethanol, using sodium bicarbonate to adjust the pH to 9-10, then adding 0.35% Tween 20 and 0.15% OP-15, and ultrasonically extracting at 30kHz and 40°C for 20min in the dark , then filtered, and the filtrate was kept in the dark at 40°C for later use; the filter residue was extracted once again under the same conditions as above, and the obtained filtrate was combined with the previous filtrate; 5% activated carbon was added to the combined filtrate, and stirred for 10 minutes at 40°C in the dark, Acidify the filtrate after filtering to remove carbon to pH = 3-4, let it stand for 20 minutes, and filter with suction to obtain crude rutin. Place the crude rutin in an oven, dry it at 40°C until it has no alco...

Embodiment 2

[0020] 80g of dried Sophora japonica was treated by dry steaming method at 70°C for 30min, then rinsed with hot water at 70°C to remove the gelatin, then dried in the air and crushed into 40 meshes. Add Sophora japonica granules with 4% borax and 1% Na 2 SO 3 and 25 times of 60-70% ethanol, using sodium bicarbonate to adjust the pH to 9-10, then adding 0.40% Tween 20 and 0.10% OP-15, and ultrasonically extracting at 30kHz and 40°C for 20min in the dark , then filtered, and the filtrate was kept in the dark at 40°C for later use; the filter residue was extracted once again under the same conditions as above, and the obtained filtrate was combined with the previous filtrate; 5% activated carbon was added to the combined filtrate, and stirred for 10 minutes at 40°C in the dark, Acidify the filtrate after filtering to remove carbon to pH = 3-4, let it stand for 20 minutes, and filter with suction to obtain crude rutin. Place the crude rutin in an oven, dry it at 40°C until it ha...

Embodiment 3

[0022] 120g of dried Sophora japonica was treated by dry steaming method at 70°C for 30min, then rinsed with hot water at 70°C to remove the gelatin, then dried in the air and crushed into 60 meshes. Add 3% borax and 1% Na to Sophora japonica granules 2 SO 3 and 30 times of 60-70% ethanol, use sodium bicarbonate to adjust the pH to 9-10, then add 0.45% Tween 20 and 0.05% OP-15, and ultrasonically extract at 30kHz and 40°C for 20min in the dark , then filtered, and the filtrate was kept in the dark at 40°C for later use; the filter residue was extracted once again under the same conditions as above, and the obtained filtrate was combined with the previous filtrate; 5% activated carbon was added to the combined filtrate, and stirred for 10 minutes at 40°C in the dark, Acidify the filtrate after filtering to remove carbon to pH = 3-4, let it stand for 20 minutes, and filter with suction to obtain crude rutin. Place the crude rutin in an oven, dry it at 40°C until it has no alco...

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Abstract

The invention discloses a novel method for extracting rutin from Japanese pagoda tree flowers. The method for extracting the rutin from the Japanese pagoda tree flowers comprises the following steps of processing dried Japanese pagoda tree flowers under 70 DEG C through a drying steaming method and airing and smashing the Japanese pagoda tree flowers; adding surface active agent with the reasonable ratio such as Tween 20 and OP-15, performing ultrasonic-assisted extraction through ethyl alcohol with the alcohol concentration to be from 60 to 70 % under a certain condition, standing extraction solution to be crystallized and obtaining rutin crude products through suction filtration; refining the rutin crude products through n-butyl alcohol, standing the rutin crude products to be crystallized and drying under 130 DEG C to obtain rutin products with the purity to be more than 98 %, wherein the yield is larger than 22 %. The method for extracting the rutin from the Japanese pagoda tree flowers is simple in operation, high in extraction efficiency and applicable to product and reality.

Description

technical field [0001] The application relates to a method for extracting rutin from Sophora japonica. Background technique [0002] Sophora japonica is the dried flowers and flower buds of Sophora japonica, a leguminous plant. It has been used as medicine for more than 2,000 years. It is listed as top grade in "Shen Nong's Materia Medica". The rutin contained in Sophora japonica is about 8% to 28% (varies according to the place of origin and harvesting time of Sophora japonica). Rutin, also known as rutin and purple quercitrin, belongs to flavonoid glycosides. It has the effects of cooling blood and stopping bleeding, clearing liver and purging fire, reducing capillary permeability and fragility, promoting cell proliferation and preventing blood cell aggregation. Anti-inflammatory, anti-allergic, diuretic, antitussive, hypolipidemic and other effects. Rutin has been used clinically as an adjuvant treatment for hypertension, to prevent other bleeding disorders caused by r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 梁玉强马亚琼白易张成亮赵永强
Owner 内蒙古昶辉生物科技股份有限公司
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