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Method for extracting effective compositions from composition of fructus ligustri lucidi and radix astragali through supercritical extraction process and products thereof

A supercritical extraction method and composition technology, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, plant/algae/fungus/moss ingredients, etc., can solve the problem of affecting product quality and clinical curative effect, and patients take a large amount , extraction rate and purity cannot meet the production and use problems

Inactive Publication Date: 2014-10-08
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there are many kinds of active ingredients of medicines that need to be extracted, the active ingredients of medicines in the Zhenqi Fuzheng preparation obtained by the above-mentioned traditional preparation process are basically crude extracts, and the extraction rate and purity cannot meet the needs of production and use, which will not only cause patients The dosage is relatively large, and it will directly affect the quality and clinical efficacy of the product

Method used

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  • Method for extracting effective compositions from composition of fructus ligustri lucidi and radix astragali through supercritical extraction process and products thereof
  • Method for extracting effective compositions from composition of fructus ligustri lucidi and radix astragali through supercritical extraction process and products thereof
  • Method for extracting effective compositions from composition of fructus ligustri lucidi and radix astragali through supercritical extraction process and products thereof

Examples

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Effect test

Embodiment 1

[0066] Example 1 of the present invention: A method for extracting polysaccharides in the chastity qi composition by supercritical extraction method is as follows: crush Astragalus membranaceus and Ligustrum lucidum to 1.0mm, dry at low temperature, and weigh them in a weight ratio of 2:1 Astragalus powder and Ligustrum lucidum powder, the two are extracted alone or after being mixed; supercritical carbon dioxide is used as the extraction agent, the entrainer is 80% ethanol, the pressure is 40MPa, the temperature is 50°C, and the flow rate of carbon dioxide is controlled at 25L / h. Extract for 3 hours to obtain an extract, evaporate the extract under reduced pressure, and dry in vacuum to obtain a polysaccharide extract.

Embodiment 2

[0067] Example 2 of the present invention: A method for extracting polysaccharides in the chastity qi composition by supercritical extraction method is as follows: crush Astragalus membranaceus and Ligustrum lucidum to 0.3 mm, dry at low temperature, and weigh them in a weight ratio of 2:1 Astragalus powder and Ligustrum lucidum powder are extracted separately or mixed; supercritical carbon dioxide is used as the extraction agent, the entrainer is 60% ethanol, the pressure is 30MPa, the temperature is 40°C, and the flow rate of carbon dioxide is controlled at 10L / h. Extract for 2 hours to obtain an extract, evaporate the extract under reduced pressure, and dry in vacuum to obtain a polysaccharide component extract.

Embodiment 3

[0068] Example 3 of the present invention: A method for extracting polysaccharides in the chastity qi composition by supercritical extraction method is as follows: crush Astragalus membranaceus and Ligustrum lucidum to 2.0 mm, dry at low temperature, and weigh them in a weight ratio of 2:1 Astragalus powder and Ligustrum lucidum powder are extracted separately or after being mixed; supercritical carbon dioxide is used as the extraction agent, the entrainer is 70% ethanol, the pressure is 50MPa, the temperature is 60°C, and the flow rate of carbon dioxide is controlled at 30L / h. Extract for 4 hours to obtain an extract, evaporate the extract under reduced pressure, and dry in vacuum to obtain a polysaccharide extract.

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Abstract

The invention discloses a method for extracting effective compositions from a composition of fructus ligustri lucidi and radix astragali through a supercritical extraction process and products thereof. The method comprises: crushing radix astragali and fructus ligustri lucidi and performing low-temperature drying, performing first extraction on radix astragali and fructus ligustri lucidi respectively or on a mixture of radix astragali and fructus ligustri lucidi by using supercritical carbon dioxide as an extracting agent, performing reduced-pressure evaporation and vacuum drying on the extracting liquid, so as to obtain a polyose-composition extracting product; performing secondary supercritical extraction on the first extraction residue, so as to obtain a flavonoid-composition extracting product; performing third supercritical extraction on the second extraction residue, so as to obtain a saponin-composition extracting product; and performing forth supercritical extraction on the thrid extraction residue, so as to obtain a terpene-composition extracting product The extraction method is capable of improving the extraction rate and the purity of the effective compositions in the composition of fructus ligustri lucidi and radix astragali, thereby reducing the dose of an astragalus membranaceus-ligustrum healthy-qi-reinforcing preparation and enabling the astragalus membranaceus-ligustrum healthy-qi-reinforcing preparation to have relatively good treatment effect.

Description

technical field [0001] The invention relates to a method for extracting active ingredients in Zhenqi composition by a supercritical extraction method and a product thereof, belonging to the technical field of preparation of Zhenqi Fuzheng preparations. Background technique [0002] Zhenqi Fuzheng preparation has the effects of invigorating qi and nourishing yin, strengthening the body and strengthening the body. Modern pharmacological experiments have proved that it can improve the immune function of the human body, protect the function of bone marrow and adrenal cortex, and promote the production of interferon; cooperate with radiotherapy and chemotherapy of tumor patients, reduce the toxic and side effects of patients during radiotherapy and chemotherapy, and promote the recovery of normal functions. Its prescription consists of Astragalus and Ligustrum lucidum. At present, the dosage forms of Zhenqi Fuzheng preparation for clinical selection include tablets, capsules, gr...

Claims

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Application Information

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IPC IPC(8): A61K36/638A61K31/715A61P37/04
Inventor 张观福
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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