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Application of cyanidin-3-oxy-glucoside in medicine for treating obesity and related diseases

A technology of glucoside and cornflower, which is applied in the field of health care products, can solve the problems that have not yet been achieved, and achieve the effects of increasing energy metabolism, improving glucose tolerance, and enhancing insulin sensitivity

Active Publication Date: 2018-01-09
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are currently no studies investigating the use of cyanidin-3-oxo-glucoside for the treatment of obesity or obesity-related disorders and for improving energy metabolism or promoting fever

Method used

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  • Application of cyanidin-3-oxy-glucoside in medicine for treating obesity and related diseases
  • Application of cyanidin-3-oxy-glucoside in medicine for treating obesity and related diseases
  • Application of cyanidin-3-oxy-glucoside in medicine for treating obesity and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Study on the anti-obesity effect of Centaurea-3-oxo-glucoside

[0041] In order to verify the anti-obesity effect of C3G (Centaurea-3-oxo-glucoside), we selected a db / db mouse model: 4 weeks old db / db male mice were randomly divided into a control group (control group, 10) and the cornflower-3-oxo-glucoside group (C3G group, 10).

[0042] Diet: Both the control group and C3G group have a normal diet (fed with low-fat feed);

[0043] Drinking water: the control group, free drinking ordinary water.

[0044] C3G group, drink water containing 1mg / ml cornflower-3-oxo-glucoside (check the average daily water consumption of db / db mice in C3G group every other day, and calculate that the average daily consumption of mice is equivalent to 200mg / kg body weight) Medicine; continuous administration.

[0045] The body weight was recorded every week of administration. After 15 weeks of continuous administration, the mice were killed by removing the eyeballs, and the liver, epididy...

Embodiment 2

[0049] Example 2 Study on the effect of bluebonnet-3-oxo-glucoside on insulin resistance

[0050] Many research results indicate that obesity is often accompanied by severe insulin resistance. For this reason, the present invention uses the mice at the 12th week of administration in Example 1 to perform the following experiments:

[0051] 1. Intraperitoneal glucose tolerance test (IPGTT)

[0052] The db / db mice 12 weeks after administration in Example 1 and the db / db mice in the control group were fasted overnight. After weighing, glucose was injected into the abdominal cavity. The injection amount per kg of body weight was 1.0g. After injection, The blood glucose was measured at 0min, 30min, 60min, 90min and 120min with a blood glucose meter.

[0053] The result is image 3 As shown, image 3 This is the effect of bluebonnet-3-oxo-glucoside on glucose tolerance in db / db mice.

[0054] by image 3 It can be seen that the fasting blood glucose curve of db / db mice in the control group wa...

Embodiment 3

[0060] Example 3 Study on the effect of cornflower-3-oxo-glucoside on energy consumption

[0061] Take the db / db mice and the db / db mice in the control group after the 9th week of administration in Example 1, use the animal metabolism measurement analysis system (LabMaster) to detect their oxygen consumption, and compare the db / db mice The temperature was measured at 25°C and 4°C.

[0062] The result is Figure 6-7 As shown, Image 6 It is the effect of cornflower-3-oxo-glucoside on oxygen consumption of db / db mice; Figure 7 This is the effect of bluebonnet-3-oxo-glucoside on the body temperature of db / db mice.

[0063] by Image 6 It can be seen that the oxygen consumption of mice in the control group during the day was 1733.43±61.96ml / h.kg, and the oxygen consumption at night was 2001.92±59.63ml / h.kg; the mice in the C3G group consumed 2065.30±85.73ml / h during the day. kg, the oxygen consumption at night was 2143.65±109.66ml / h.kg, and the daytime oxygen consumption of the C3G gr...

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Abstract

The invention provides an application and using method of cornflower-3-oxo-glucoside in medicines for treating obesity and obesity-related diseases and improving energy metabolism or promoting pyrexia. Meanwhile, the invention also provides a medicine for treating obesity and obesity-related diseases and improving energy metabolism or promoting pyrexia, wherein the medicine comprises the cornflower-3-oxo-glucoside. The test proves that the cornflower-3-oxo-glucoside can effectively inhibit obesity of db / db model mice and improve insulin resistance of the db / db model mice. The adaptability of an organism on cold stimulation is improved by increasing the energy metabolism level of the organism, improving the glucose tolerance of the organism, enhancing insulin sensitivity of tissues and activating heat production of the organism, and a novel way is developed for treatment of the obesity and related diseases.

Description

Technical field [0001] The invention belongs to the field of health care products, and specifically relates to the application of a natural extract, in particular to a plant polyphenol-Cyanidin-3-O-glucoside chloride (Cyanidin-3-O-glucoside chloride) for the treatment of obesity Or obesity-related diseases and drugs that increase energy metabolism or promote fever. Background technique [0002] The occurrence of obesity is the result of the body's energy metabolism disorder, that is, when the body's energy intake exceeds energy consumption, almost all of the remaining energy is converted into triglycerides, which are stored in white adipose tissue (WAT). At present, with the improvement of people's living standards and changes in dietary structure, excessive food intake and reduction of physical activity and exercise have led to the imbalance of energy metabolism in people's body. Obesity has become an unavoidable problem for humans. [0003] Obesity has shown an explosive epidemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P3/04A61P3/10A61P3/00A61P5/50
Inventor 战吉宬游义琳黄卫东孙翔宇
Owner CHINA AGRI UNIV
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