Model for protecting mouse ulcerative colitis by antibacterial peptide C-BF
A technique for ulcerative colitis and C-BF applied in the field of biomedicine
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[0026] The present invention will be described in detail below in conjunction with the accompanying drawings, and the embodiments are only for describing but not limiting the present invention.
[0027]1: We first confirmed that the antimicrobial peptide C-BF can be absorbed by the peritoneum by using in vivo imaging technology, but it is completely metabolized after remaining in the body for 24 hours. figure 1 In order to confirm the absorption of antimicrobial peptide C-BF into the intestinal cavity by using in vivo imaging technology; from figure 1 We can confirm that C-BF spreads from the intestinal cavity to the whole body in about 10 minutes, but C-BF is metabolized or excreted in the body within 24 hours, so each injection of C-BF should not exceed 24 hours;
[0028] 2: On this basis, we established a mouse model of ulcerative colitis induced by 3% DSS, and the experimental grouping and design were as follows: figure 2 :
[0029] C-BF dose: 5mg / kg mouse body weight, ...
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