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Phenethyl resorcinol nanostructured lipid carrier and preparation method thereof

A technology of phenylethyl resorcinol and nanostructured lipids, which is applied in the field of nanostructured lipid carriers and its preparation, can solve the problems of reduced bioavailability of phenylethylresorcinol, and achieve a simple and reliable preparation method. control, good photostability, and high water solubility

Active Publication Date: 2014-09-10
上海复旦张江生物医药股份有限公司
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These problems lead to greatly reduced bioavailability of phenethyl resorcinol

Method used

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  • Phenethyl resorcinol nanostructured lipid carrier and preparation method thereof
  • Phenethyl resorcinol nanostructured lipid carrier and preparation method thereof
  • Phenethyl resorcinol nanostructured lipid carrier and preparation method thereof

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Embodiment Construction

[0032] The specific implementation manners of the present invention will be described below in conjunction with the examples. It should be understood that these examples are used to illustrate the present invention and not to limit the scope of the present invention. The implementation conditions used in the examples can be further adjusted according to the conditions of specific manufacturers, and the implementation conditions not indicated are usually the conditions in routine experiments.

[0033] 1. Preparation of phenylethyl resorcinol nanostructured lipid carrier

[0034] The formula of embodiment 1~4 is as shown in table 1.

[0035] The formula of table 1, embodiment 1~4

[0036]

[0037]

[0038] The preparation process comprises the following steps:

[0039] 1. Weigh the lipid material and emulsifier respectively according to the formula, put them into a beaker, heat in a water bath at about 75°C until completely melted, and obtain a liquid oil phase;

[004...

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Abstract

The invention discloses a phenethyl resorcinol nanostructured lipid carrier, which contains 0.5-5% of an active component composed of phenethyl resorcinol, 2.5-30% of a carrier composed of a lipid material wrapping the active component, 0.5-5% of an emulsifier, and the balance water. The phenethyl resorcinol nanostructured lipid carrier has good light stability and high water solubility, and the used grease and emulsifier have good compatibility with skin, so that the phenethyl resorcinol nanostructured lipid carrier can be conveniently used in production field of cosmetics. The invention also discloses a preparation method of the nanostructured lipid carrier. The method is simple and controllable, has good repeatability, and can be used for preparing the nanostructured lipid carrier with a content of 0.5-5%, an encapsulation rate of 85-95%, and an average particle size of 100-300nm.

Description

technical field [0001] The invention relates to a nanostructured lipid carrier and a preparation method thereof. The active ingredient of the nanostructured lipid carrier is phenylethyl resorcinol. Background technique [0002] Phenylethyl Resorcinol, molecular formula C 14 h 14 o 2 , the full chemical name is 4-(1-phenylethyl)-1,3-benzenediol, the relative molecular weight is 214.26, and the trade name is 377, is a white crystalline solid with low odor. Soluble in ethanol, propylene glycol, butanediol, pentylene glycol, the solubility in water at 25°C is 265mg / L. [0003] Phenylethyl resorcinol is an effective whitening ingredient developed by Symrise, which has a strong antioxidant effect and strongly inhibits the activity of tyrosinase, thereby reducing the production of melanin. Skin tests showed that 0.5% concentration of 377 is more effective than 1% concentration of kojic acid. In 2012, the China Food and Drug Administration (SFDA) has approved phenylethyl re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/85A61K8/60A61K8/55A61K8/33A61K8/04A61Q19/02
Inventor 孙靖毛文学余音
Owner 上海复旦张江生物医药股份有限公司
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