Detection method for preparing puerperal blood-stasis dispersing capsule

A detection method and capsule technology, which are applied to measurement devices, instruments, scientific instruments, etc., can solve the problems of incomplete preparation methods, unable to meet the needs of actual production, and difficult to achieve therapeutic effects, and achieve simple detection methods and controlled production. Cost, effect of precise control of quality

Active Publication Date: 2014-08-13
JIANGXI MINJI MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there have been relevant domestic patent applications such as 2013107103201 which disclose a postpartum stasis-removing granule and its preparation method, but the preparation method disclosed in this patent is not complete, and there is also a lack of effective detection methods to ensure product quality
As we all know, the ingredients of traditional Chinese medicine complement each other, and the requirements for the preparation process are very high, otherwise it will be difficult to achieve the expected therapeutic effect
Therefore, the preparation methods of related products in the prior art all cannot meet the needs of actual production.

Method used

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  • Detection method for preparing puerperal blood-stasis dispersing capsule
  • Detection method for preparing puerperal blood-stasis dispersing capsule
  • Detection method for preparing puerperal blood-stasis dispersing capsule

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Motherwort 1248g Angelica 156g Chuanxiong 178g Paojiang 78g

[0027] Preparation:

[0028] For the above four flavors, take 20g each of motherwort, angelica, and chuanxiong, and grind them into fine powder, and set aside. Add 10 times the amount of leftover angelica, chuanxiong, and Paojiang to distill and extract for 3 hours, collect volatile oil, add 10 times the amount of dregs and remaining motherwort, respectively, Decoct with 8 times the amount of water twice, each time for 2 hours, and the second time for 1 hour, filter, combine the filtrates, concentrate to a thick paste with a relative density of 1.35 (50°C), add the above fine powder, mix well, and dry. Make granules, then dry, add volatile oils such as angelica, mix well, pack into capsules, and make 1000 granules, and you get it.

[0029] Detection method:

[0030] (1) Take 10 capsules of this product, pour out the contents, grind finely, add 10ml of absolute ethanol for ultrasonic treatment for 20 minutes...

experiment example 1

[0038] Experimental Example 1: TLC Identification of Chinese Angelica and Chuanxiong

[0039]Angelica and Chuanxiong were used as positive controls (provided by China Institute for the Control of Pharmaceutical and Biological Products, batch number 120927-200310, 120918-200406), and n-hexane-ethyl acetate (9:1) was used as the expansion point, and the spots after expansion were viewed at 365 nm , the fluorescent spots are round and round, and the separation effect is good. In addition, take other medicinal materials that do not contain angelica and chuanxiong in the prescription to make a negative sample according to the preparation method, and then make a negative sample solution according to the preparation method of the test solution. After three batches of samples and negative control tests, negative without interference.

[0040] Which attached figure 1 Among them, 1. Three batches of samples of Angelica as reference medicinal material 2. Three batches of samples of Chu...

experiment example 2

[0041] Experimental example 2: TLC identification of motherwort medicinal materials

[0042] With stachydrine hydrochloride reference substance (National Institute for the Control of Pharmaceutical and Biological Products, batch number 110712-200306) and motherwort reference medicinal material (National Institute for the Control of Pharmaceutical and Biological Products, batch number 1120912-200306) as positive controls, once compared I: n-butanol- Developing agents such as hydrochloric acid-water (4:1:0.5), II: acetone-absolute ethanol-hydrochloric acid (10:6:1), among which the spots after developing with developing agent II are rounded and the separation effect is good. Take other medicinal materials that do not contain motherwort in the prescription to make a negative sample according to the preparation method, and then make a negative sample solution according to the preparation method of the test solution. After three batches of samples and negative control tests, negati...

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Abstract

The invention relates to a detection method for preparing a puerperal blood-stasis dispersing capsule. The method comprises the steps of carrying out thin-layer chromatography identification on ligusticum wallichii, angelica and motherwort, and carrying out high performance liquid chromatography testing on the content and limit of ferulic acid.

Description

technical field [0001] The invention relates to a detection method for preparing postpartum Zhuyu capsules. Background technique [0002] Postpartum congestion after childbirth is mainly leftover blood and turbid fluid in the uterus, which is caused by abnormal circulation of Qi and blood, blood stasis and Qi stagnation, and is one of the common clinical diseases in obstetrics and gynecology. [0003] Traditional Chinese medicine believes that the pathology of this disease is mainly due to abnormal circulation of qi and blood, blood stasis and stagnation of qi. Western medicine believes that the cause is mainly incomplete uterine recovery, when part of the placenta, fetal membranes remain or infection affects uterine contraction and recovery; Local factors such as swelling and uterine fibroids can affect the incomplete restoration of the uterus. Secondly, after cesarean section, the incision in the uterine wall is dehiscated, the hemostasis is not complete during the opera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
Inventor 李明辉王刚
Owner JIANGXI MINJI MEDICINE
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