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Application of L-menthone in preparing anti-depression medicament

A levomenthone, antidepressant technology, applied in the field of medicine, can solve the problems of many side effects, easy recurrence, poor drug tolerance, etc., and achieves the effect of increasing sugar water preference, shortening immobility time, and significantly resisting experimental depression in mice. Effect

Inactive Publication Date: 2014-08-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these traditional antidepressants may take effect only 2 to 4 weeks after medication, and they only work for about 70% of patients. At the same time, there are many side effects, poor patient tolerance to drugs, and easy relapse.

Method used

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  • Application of L-menthone in preparing anti-depression medicament
  • Application of L-menthone in preparing anti-depression medicament
  • Application of L-menthone in preparing anti-depression medicament

Examples

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Embodiment 1

[0013] Influence test of levomenthone described in embodiment 1 invention on chronic unpredictable mild stimulation depression model mice

[0014] 1 Experimental method

[0015] 1.1 Establishment of chronic unpredictable mild stimulus depression model

[0016] Establish a chronic mild unpredictable stress model. Among them, the chronic mild stimulation includes: (1) tail suspension for 10 minutes, (2) shaking the mouse cage for 10 minutes, (3) noise (unFM radio) for 3 hours, (4) cage tilt (about 30°) for 8 hours or overnight, (5) wet bedding (150ml water) for 8 hours or overnight, (6) foreign matter for 8 hours or overnight, (7) lighting overnight, (8) tail clamping for 5 minutes, (9) restraint for 10 minutes, ( 10) fasting for 8 hours or overnight, (11) fasting for 8 hours or overnight.

[0017] The model group, fluoxetine group, high-dose and low-dose levomenthone groups were given the above-mentioned chronic mild stress for 3 weeks. The above two different stresses were...

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Abstract

The invention relates to the field of medicines, and particularly relates to application of L-menthone in preparing an anti-depression medicament. Results of weight-appearance experiments, sucrose preference tests, open field tests, forced swimming tests and the like on a mouse chronic unpredictable mild stress model prove that L-menthone has remarkable anti-depression activity, and can be used for preparing anti-depression medicaments.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an application of levomenthone in the preparation of antidepressant drugs. Background technique [0002] L-Menthone (L-Menthone), colorless oily liquid, soluble in organic solvents, slightly soluble in water. CAS number: 14073-97-3, its structural formula is: [0003] [0004] Natural levomenthone exists in traditional Chinese medicines such as Schizonepetae, Peppermint, and Scutellaria baicalensis. Nepeta is the dry aerial part of the Lamiaceae plant Nepeta. Slightly warm in nature, pungent in taste, returns to Liver and Lung Meridian. It has the functions of relieving the exterior and dispelling wind, clearing the rash, clearing the head, benefiting the throat, eliminating sores, relieving itching, hemostasis, and opening the nose. Mint is the dry aerial part of the perennial herbaceous plant Mint of the Lamiaceae Mentha genus. Peppermint tastes pungent and cool, and belongs to ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P25/24
Inventor 傅强马世平薛劲松邓雪阳马占强贺雅婷李虹燕
Owner CHINA PHARM UNIV
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