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A kind of preparation method of coated compound vitamin microcapsule

A vitamin and coating technology, which is applied in the field of preparation of coated composite vitamin microcapsules, can solve the problems of being unable to tolerate the acidic environment of the stomach, the death of probiotics lactic acid bacteria and bifidobacteria, and the inability to achieve probiotic effects, etc. , to achieve the effects of avoiding the loss of bacterial count, good embedding efficiency and simple preparation method

Active Publication Date: 2016-04-06
NANHAI CHANTAI ANIMAL PHARMACY FOSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, after lactic acid bacteria and bifidobacteria are ingested by humans or animals, they cannot tolerate the acidic environment in the stomach of humans or animals, resulting in the death of probiotic lactic acid bacteria and bifidobacteria, which cannot achieve the desired probiotic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of preparation method of coated compound vitamin microcapsule, with mass concentration 20% sodium alginate solution, mass concentration 10% CaCl 2 Solution, 50% polyethylene glycol solution and 10% palmitic acid ester solution are the mixed solution of the coating wall material. At a temperature of 57°C, add the compound vitamin bacteria in a constant temperature magnetic stirrer Stir for 20 minutes, after uniformity, cool to 50°C and centrifuge to prepare microcapsules. In the present invention, the compound vitamin bacteria are preferably Bacillus subtilis, lactic acid bacteria and saccharomyces.

[0024] The preparation method of the described coating compound vitamin microcapsule, sodium alginate solution, CaCl 2 The weight percentages of solution, polyethylene glycol solution and palmitate solution are: 18%, 12%, 60% and 8%.

[0025] In the preparation method of the coated composite vitamin microcapsules, the weight ratio of the coating wall material mixtu...

Embodiment 2

[0029] A kind of preparation method of coated compound vitamin microcapsule, with mass concentration 20% sodium alginate solution, mass concentration 10% CaCl 2 Solution, polyethylene glycol solution with mass concentration of 50% and palmitic acid lipid solution with mass concentration of 10% are the mixed solution of coating wall material in the mixing system. Stir for 25 minutes, after being uniform, cool to 50°C, and centrifuge to prepare microcapsules. In the present invention, the compound vitamin bacteria are preferably Bacillus subtilis, lactic acid bacteria and saccharomyces.

[0030] The preparation method of the described coating compound vitamin microcapsule, sodium alginate solution, CaCl 2 The weight percentages of solution, polyethylene glycol solution and palmitate solution are: 21%, 12%, 48% and 19%.

[0031] In the preparation method of the coated composite vitamin microcapsules, the weight ratio of the coating wall material mixture to the composite vitamin...

Embodiment 3

[0035] A kind of preparation method of coated compound vitamin microcapsule, with mass concentration 20% sodium alginate solution, mass concentration 10% CaCl 2 Solution, polyethylene glycol solution with a mass concentration of 50% and palmitic acid lipid solution with a mass concentration of 10% are the mixed solution of the coating wall material. Stir for 30 minutes, after being uniform, cool to 50°C, and centrifuge to prepare microcapsules. In the present invention, the compound vitamin bacteria are preferably Bacillus subtilis, lactic acid bacteria and saccharomyces.

[0036] The preparation method of the described coating compound vitamin microcapsule, sodium alginate solution, CaCl 2 The weight percentages of solution, polyethylene glycol solution and palmitate solution are: 22%, 8%, 60% and 10%.

[0037] In the preparation method of the coated composite vitamin microcapsules, the weight ratio of the coating wall material mixture to the composite vitamin is 20:1.

[...

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Abstract

Disclosed is a preparation method of a compound bacteria coated microcapsule. Sodium alginate, CaCl2, polyethylene glycol and palmitate are used as a coating wall material mixed solution, which is stirred uniformly with compound bacteria at the temperature of 50-60 DEG C by a constant temperature magnetic stirrer; and the mixture is cooled and subjected to centrifugation to prepare the microcapsule. The compound bacteria is bacillus bacteria, lactic acid bacteria and yeast. The invention provides a simple preparation method, the prepared compound bacteria microcapsule has good encapsulation yield and encapsulation efficiency, and can pass through the stomach and dissolve in intestinal tracts, so as to avoid bacteria number loss of living bacteria in the stomach and produce the biggest effect in the intestinal tracts.

Description

technical field [0001] The invention relates to a method for preparing microcapsules coated with compound vitamin bacteria, and belongs to the technical field of microcapsule coating. Background technique [0002] In recent years, as the disadvantages caused by the abuse of antibiotics have been increasingly recognized by people, in animal husbandry, the use of non-toxic, harmless and residue-free microecological preparations has become more and more widely used, and the compound vitamin microecological preparations are convenient. is one of them. When the compound vitamin bacteria reaches a certain amount in the intestinal tract, it can antagonize pathogenic microorganisms, adjust the balance of animal digestive tract microflora, enhance the body's immunity, inhibit the formation of tumor cells, and reduce cholesterol levels, etc. However, at present, most of the domestic lactic acid bacteria are the main fungi. Most of the lactic acid bacteria are anaerobic bacteria or fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/064A23K20/00A61K47/36A61P37/04A61P3/00A61K35/744A61K35/742A23K20/174
Inventor 郭海强
Owner NANHAI CHANTAI ANIMAL PHARMACY FOSHAN
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