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Drug for preventing and treating intimal hyperplasia after arterial intimal injury and preparation method thereof

A technology for intimal hyperplasia and membrane damage, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of high toxicity and side effects, easy liver damage and bleeding, and achieve the prevention and treatment of intimal hyperplasia and medicinal taste The effect of less and simple drug composition

Active Publication Date: 2016-03-23
FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, for the prevention and treatment of intimal hyperplasia after arterial intimal injury, statins and antiplatelet drugs are used in Western medicine, which have serious side effects and are prone to liver injury and bleeding. Drugs for Membrane Proliferation

Method used

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  • Drug for preventing and treating intimal hyperplasia after arterial intimal injury and preparation method thereof
  • Drug for preventing and treating intimal hyperplasia after arterial intimal injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Soak 10g of rhubarb, 15g of cassia twig, 20g of salvia miltiorrhiza, 14g of chuanxiong, 10g of earthworm, and 15g of honeysuckle in 15 times the amount of water for 40 minutes, then boil it for 70 minutes with strong fire for the first time, and add 10 times the amount of water for the second time. Boil on low heat for 50 minutes, add 6 times the amount of water for the third time and cook on slow fire for 30 minutes, combine the three decoctions, filter through gauze, concentrate in a water bath at 100°C to 150mL, and store in a refrigerator at 4°C; Zocor 40mg / tablet, batch number: J20060032, provided by Hangzhou MSD Pharmaceutical Co., Ltd.; aspirin 100mg / tablet, batch number: BTA6015, provided by Bayer Pharmaceutical Group Co., Ltd.; after grinding, dissolve in double distilled water, 13.5ml is quite comfortable Drop 1.5mg, aspirin 3.7mg, store in a 4-degree refrigerator to get the finished product.

Embodiment 2

[0022] Soak 20g of rhubarb, 10g of cassia twig, 18g of salvia miltiorrhiza, 10g of chuanxiong, 15g of earthworm, and 10g of honeysuckle in 15 times the amount of water for 40 minutes, then boil for 70 minutes with strong fire for the first time, and add 10 times the amount of water for the second time Boil on low heat for 50 minutes, add 6 times the amount of water for the third time and cook on slow fire for 30 minutes, combine the three decoctions, filter through gauze, concentrate in a water bath at 100°C to 150mL, and store in a refrigerator at 4°C; Zocor 40mg / tablet, batch number: J20060032, provided by Hangzhou MSD Pharmaceutical Co., Ltd.; aspirin 100mg / tablet, batch number: BTA6015, provided by Bayer Pharmaceutical Group Co., Ltd.; after grinding, dissolve in double distilled water, 13.5ml is quite comfortable Drop 1.5mg, aspirin 3.7mg, store in a 4-degree refrigerator to get the finished product.

Embodiment 3

[0024] Rhubarb 16g, Guizhi 12g, Salvia miltiorrhiza 16g, Ligusticum chuanxiong 13g, Earthworm 11g, honeysuckle 14g Soak in 15 times the amount of water for 40 minutes, decoct with strong fire for 70 minutes for the first time, add 10 times the amount of water for the second time and use slow fire Boil for 50 minutes, add 6 times the amount of water for the third time and decoct with a slow fire for 30 minutes, combine the three decoctions, filter through gauze, concentrate in a water bath at 100°C to 150mL, and store in a refrigerator at 4°C; Zocor 40mg / Tablets, batch number: J20060032, provided by Hangzhou MSD Pharmaceutical Co., Ltd.; aspirin 100mg / tablet, batch number: BTA6015, provided by Bayer Pharmaceutical Group Co., Ltd.; after grinding, dissolve in double distilled water, 13.5ml contains Zocor 1.5 mg of aspirin, 3.7 mg of aspirin, and stored in a 4-degree refrigerator to obtain the finished product.

[0025] Experimental report made by taking the medicine for prevent...

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Abstract

The invention relates to a medicine for preventing and treating intimal hyperplasia after damage of endarterium and a preparation method thereof in the technical field of medicines. A formula of the medicine for preventing and treating the intimal hyperplasia after damage of endarterium comprises rheum officinale, cassia twig, salviae miltiorrhizae, szechwan lovage rhizome, earthworm and honeysuckle. The preparation method of the medicine for preventing and treating the intimal hyperplasia after damage of endarterium comprises the following steps: soaking rheum officinale, cassia twig, salviae miltiorrhizae, szechwan lovage rhizome, earthworm and honeysuckle for 40 minutes with 15 times amount of water, decocting with a strong fire for 70 minutes for the first time, adding 10 times amount of water and decocting with a slow fire for 50 minutes for the second time, adding 6 times amount of water and decocting with a slow fire for 30 minutes for the third time, putting the decocted liquid medicines together, filtering with a gauze, concentrating to 150ml through water bath at the temperature of 100 DEG C, and storing in a refrigerator at the temperature of 4 DEG C. The medicine for preventing and treating the intimal hyperplasia after damage of endarterium has the advantages of simple composition, clear compatibility, less drug flavour, low cost and definite and obvious curative effect, and animal experiments prove that the medicine for preventing and treating the intimal hyperplasia after damage of endarterium has the effects of inhibiting platelet aggregation, inhibiting expression of PDGF-B, obviously preventing and treating the intimal hyperplasia after damage of endarterium and preventing restenosis after percutaneous coronary intervention, so that the medicine for preventing and treating the intimal hyperplasia after damage of endarterium can be easily accepted by a patient.

Description

technical field [0001] The invention relates to a Chinese herbal medicine in the technical field of medicine, in particular to a medicine for preventing and treating intimal hyperplasia after arterial intima injury and a preparation method thereof. Background technique [0002] PTCA mechanically dilates blood vessels and expands the vessel wall, which is an exogenous trauma that injures collaterals, causing poor blood flow and blood stasis, which belongs to the category of "blood stasis syndrome". "Shengji Zonglu. General Discussion on Injury Breaks" says: "The theory says: the pulse is the house of blood, and the blood flows through the veins... If due to an injury, the meridians are moved internally, the way of blood travels, it cannot be unified, and the blood stasis does not disperse. , then it is swelling and pain." "Warm Jingwei. Fang Lun" also says: "The blood cannot flow through the collateral injury... The injured part is stasis, which accumulates for a long time wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61P9/00A61K35/62
Inventor 宫丽鸿
Owner FIRST AFFILIATED HOSPITAL OF LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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