Injection type directional sustained-release paeonol thermosensitive gel and its preparation method

Abstract

The invention relates to an injection type directional sustained-release paeonol thermosensitive gel and its preparation method. The gel is obtained by dissolving paeonol in a water based solution, and solidifying, and the water based solution is prepared by using chitosan, sodium beta-glycerophosphate, a hydrochloric acid solution, a sodium hydroxide solution and deionized water through certain steps according to a certain ratio. The method concretely comprising the following steps: rapidly dissolving paeonol in the water based solution at 40DEG C to form an injection mixed solution, and injecting the mixed solution into 37DEG C environment to solidify in order to obtain the gel, and the above drug is uniformly dispersed in a gel matrix in a dissolving state in order to realize the slow drug release, so it is beneficial for realizing the minimally invasive filling of defect tissues, and directionally slowly release the paeonol drug to realize antibiosis, antiphlogosis and pain easing in order to make the drug effect more lasting.

Description

technical field [0001] The invention relates to a paeonol drug and a preparation method thereof, in particular to an injection-type directional slow-release paeonol temperature-sensitive gel and a preparation method thereof. Background technique [0002] Paeonol is white or yellowish lustrous crystal, melting point 49°C-51°C, easily soluble in ethanol and methanol, slightly soluble in water, soluble in hot water, insoluble in cold water. It is mainly extracted from the dry root or whole plant of Xu Changqing of Asclepiaceae or the root bark or stem bark of Paeoniaceae plant peony. [0003] Paeonol has the functions of expelling wind and analgesia, detoxifying and reducing swelling, calming the central nervous system, anti-inflammatory, anti-allergy and regulating immunity, etc. It can be used for various pains, and can also be used for pruritus. The dosage forms of paeonol include oral paeonol tablets, soft capsules, and dripping pills, paeonol ointment, plaster, and patch ...

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that the paeonol injection in the prior art cannot guarantee the long-term effective concentration of the drug at the affected part, the present invention provides an injection-type directional slow-release paeonol temperature-sensitive gel and a preparation method thereof. Quickly dissolves in water-based solution at 40°C to form an injectable mixed solution. When the mixed solution is injected into an environment at 37°C, it will solidify into a gel, and the drug will be evenly dispersed in the gel matrix in the dissolved state. Achieving slow release of drugs is not only beneficial to achieve minimally invasive filling of defect tissue, but also directional slow release of paeonol drug antibacterial, anti-inflammatory and analgesic

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