A kind of industrial production method of 2-(4-methoxyphenoxy) sodium propionate

A methoxyphenoxy and production method technology, applied in the field of compound preparation, can solve the problems of high energy consumption, complex purification steps, low product purity and the like, and achieve mild reaction conditions, simplified production procedures and high product purity. Effect

Active Publication Date: 2016-03-02
GUANGDONG GUANGYI TECH IND
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, the purification process of natural 2-(4-methoxyphenoxy)sodium propionate is complicated, and the price of purified raw materials is relatively high. For this reason, the chemical preparation method of this substance has been studied at home and abroad, and the US patent US4,544,565 design The preparation method of this kind of substance has been disclosed, but the yield of this method is low, and the purity of the obtained product is low, and it is difficult to meet the standard used as a food additive; Chinese patent CN200910273148.1 is a kind of sweetness inhibitor 2-(4-methoxy The synthetic method of phenoxy)sodium propionate uses p-methoxyphenol and ethyl 2-chloropropionate as raw materials, and uses dehydrated alcohol as solvent to synthesize. The method has complicated purification steps, high energy consumption, and production cost High, not conducive to industrial production

Method used

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  • A kind of industrial production method of 2-(4-methoxyphenoxy) sodium propionate
  • A kind of industrial production method of 2-(4-methoxyphenoxy) sodium propionate
  • A kind of industrial production method of 2-(4-methoxyphenoxy) sodium propionate

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Embodiment 1

[0028] An industrial production method of sweet taste inhibitor 2-(4-methoxyphenoxy) sodium propionate, the specific processing steps include:

[0029] (1) Take the following raw materials: 10kg of p-methoxyphenol, 10kg of sodium hydroxide, 0.12kg of potassium iodide, and 100kg of water, add them to the reaction vessel, stir at room temperature for 30 minutes, and heat the reaction vessel after mixing evenly to make The above mixed raw materials are heated up to 60°C, and the temperature is kept at 60°C to 70°C, and 11.85kg of methyl 2-chloropropionate is added dropwise thereto. Under the action of catalyst potassium iodide, p-methoxyphenol and Methyl 2-chloropropionate reacts, keep the temperature during the reaction at 60°C-90°C, and at the same time, sodium hydroxide is continuously neutralized with the acid generated in the reaction, so that the reaction is always in the direction of positive reaction. After 12 hours of reaction Finish;

[0030] (2) Cool the product to no...

Embodiment 2

[0042] An industrial production method of sweet taste inhibitor 2-(4-methoxyphenoxy) sodium propionate, the specific processing steps include:

[0043] (1) Add 10kg of p-methoxyphenol, 10kg of sodium hydroxide, 0.12kg of sodium iodide, and 100kg of water into the reaction vessel, stir at room temperature for 30 minutes, mix the raw materials evenly, and then heat the reaction vessel to make the mixed The raw material is heated to 60°C, and the temperature of the mixed raw material is kept at 60°C to 70°C, 11.85kg of methyl 2-chloropropionate is added thereto, and stirred while adding, after adding methyl 2-chloropropionate, Continue heating to keep the reaction temperature at 90°C, and end the reaction after 12 hours;

[0044] (2) Cool the product to normal temperature, add a sulfuric acid solution with a mass fraction of 50% to the reacted mixed solution dropwise until the pH of the mixed solution is 2.0, stop the dropwise addition, and then lower the temperature of the mixed...

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Abstract

The invention relates to the technical field of a preparation method of a compound, and especially relates to an industrial production method of a sweetness inhibitor 2-(4-methoxyphenoxy)sodium propionate. The method comprises the following steps: taking methoxyphenol and methyl 2-chloropropionate as raw materials, under the effect of sodium hydroxide and a catalyst, taking water as a solvent, reacting for 6-24 hours at the temperature of 60-90 DEG C to obtain the product 2-(4-methoxyphenoxy)propionic acid; placing the 2-(4-methoxyphenoxy)propionic acid and sodium hydroxide in ethanol, heating, and reacting to obtain 2-(4-methoxyphenoxy)sodium propionate. According to the invention, water is taken as a solvent, the impurity in the generated product can be effectively removed, the synthesis and purification treatment processes are simple, the purity of the product is high, and the industrial production method is suitable for industrial production of 2-(4-methoxyphenoxy)sodium propionate.

Description

technical field [0001] The invention relates to the technical field of compound preparation, in particular to an industrial production method of 2-(4-methoxyphenoxy)sodium propionate. Background technique [0002] Sugar plays a pivotal role in the food field. It can be used not only as a sweetener, but also as antiseptic, preservation, expansion, color enhancement, flavor enhancement, dispersion, loosening, bonding and shaping, etc. It has delicate and lubricating taste characteristics , is an indispensable basic raw material in food processing. When some foods lack sugar, their texture will deteriorate and the shelf life will be greatly shortened; but when the sugar content is high, they will feel too sweet and too greasy, which will affect the taste of the food, and the appearance of sweetness inhibitors just Solved the problem of "too sweet and too greasy". [0003] Sodium 2-(4-methoxyphenoxy)propionate is one of the sweetness inhibitors, a natural substance present in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C59/68C07C51/41C07C51/367
CPCC07C51/367C07C51/412C07C59/68
Inventor 何松黄凯李炎松
Owner GUANGDONG GUANGYI TECH IND
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