Method for preparing veterinary heat-clearing and detoxifying oral liquid

Abstract

The invention belongs to the technical field of preparation of veterinary Chinese medicinal oral liquid, and in particular relates to a method for preparing veterinary heat-clearing and detoxifying oral liquid. The method comprises the steps of crushing of raw medicinal materials, screening, enzymolysis, decocting, micro-filtration, ultra-filtration, reduced pressure concentration, volume setting and the like. Compared with the prior art, the method has the advantages that plant cell walls can be hydrolyzed with an enzyme more effectively, so that the dissolution rate of active ingredients of the medicinal materials is improved; and by combining the micro-filtration and ultra-filtration technologies, impurities are effectively removed from the medicinal liquid, the clarity of the solution is higher, the loss of the active ingredients of the medicinal materials is less, and the clinical treatment effect of the medicaments is well guaranteed. By reasonably matching the bio-enzyme and using the bio-enzyme to assist in extracting the active ingredients in the medicinal materials, the content of key effect ingredients in the medicinal liquid is effectively improved, so that the quality of the product is well improved, and the oral liquid has good popularization and application values.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary traditional Chinese medicine oral liquid, and in particular relates to a preparation method of veterinary Qingwenjiedu oral liquid. Background technique [0002] Qingwen Jiedu Oral Liquid is a traditional Chinese medicine oral liquid for livestock and poultry included in the second volume of "Veterinary Drug Local Standards Upgraded to National Standards" (China Agricultural Press, June 2011, first edition). Zizi, Scutellaria, Forsythia, Scrophulariaceae and Banlangen. This product clears heat and detoxifies, mainly treats fever caused by exogenous factors, and is clinically used for the prevention and treatment of various viral diseases in chickens. [0003] At present, the preparation method of Qingwenjiedu oral liquid in the second volume of "Veterinary Drug Local Standards Upgrading to National Standards" is as follows: taking the preparation of 1000mL oral liquid as an exam...

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine extraction methods such as hot water, acid, alkali, and organic solvent extraction methods are hindered by the main component of cell walls, cellulose, and often have low extraction efficiency, and the yield of active ingredients is low, and a large number of active ingredients are not available in plant cell walls. released into the extraction medium

At the same time, the traditional impurity removal process usually uses alcohol precipitation method, acid-base method and flocculation precipitation method to remove impurities, which has low efficiency and tends to lose more active ingredients, which greatly reduces the economic benefits of preparation.

[0005] In the prior art, the document of patent No. 2008100526420 (a method of extracting Qingwenjiedu oral liquid by using cellulase) discloses a method using a single cellulase A method for preparing Qingwenjiedu oral liquid. Although the method uses cellulase to enzymatically hydrolyze plant cell walls, the patent discloses insufficient enzymatic activity, and there is a problem with the hemicellulose and pectin contained in the cell walls of medicinal materials. The shortcomings of poor wall-breaking effect such as quality and quality affect the maximum dissolution of active ingredients, so there is still a lot of room for improvement in the preparation method of Qingwen Jiedu Oral Liquid

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