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Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage

A technology for acute kidney injury and prognosis, applied in the fields of biochemical equipment and methods, disease diagnosis, microbiological determination/testing, etc., can solve problems such as not describing enough background technology, affecting novelty or creativity

Inactive Publication Date: 2014-07-09
UNIV DE LOS ANDES
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  • Abstract
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Problems solved by technology

[0091] Accordingly, the prior art does not describe sufficient background art to affect the novelty or inventive step of the present invention

Method used

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  • Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage
  • Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage
  • Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage

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Embodiment Construction

[0095] The present invention relates to a method for monitoring, diagnosing and / or prognosing said early acute kidney injury and determining therapy in a subject suffering from said early acute kidney injury, said method comprising the steps of: a) providing a urine sample; b ) enriching said urine sample for exosomes present in said urine sample using at least one immunopurification step; c) detecting markers of acute kidney injury (AKI) in exosomes.

[0096] In one embodiment, the urine samples were obtained from the first morning void of intubated patients and the second void of other patients and were kept at -80°C until analysis.

[0097] The present invention contemplates at least one immunopurification step as a means for enriching said urine sample for exosomes. In particular, the enrichment of exosomes is allowed by the use of antibodies against the intracellular, extracellular or arbitrary domains of specific proteins that are preferentially and differentially expres...

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Abstract

The present invention relates to a method and a kit for monitoring, diagnosis, prognosis of acute kidney injury in early stage and determination of treatment in subjects suffering thereof. The method comprises the steps of a) providing a urine sample; b) enriching the urine sample in exosomes present in the urine sample using at least one step of immunopurification; c) detecting an acute kidney injury (AKI) marker in the exosome.

Description

technical field [0001] The present invention relates to methods and kits for monitoring, diagnosing and / or prognosing early acute kidney injury and determining therapy in a subject suffering from said early acute kidney injury. Background technique [0002] The kidney is an organ that performs a variety of functions in the body, including removing bodily wastes produced during metabolism and returning the body's essential substances to the blood, thus also regulating the volume and composition of body fluids. The maintenance of the body's water and electrolyte balance is attributed to renal function (Guyton A., Hall J.E. 2001, Medical Physiology Treaty, 10th ed. Mexico DF, Mexico: McGraw-Hill Interamericana). [0003] Kidney disease is one of the most important causes of death in many countries. As early as 1994, more than 15 million people in the United States developed kidney disease, leading to poor patient quality of life and death (Guyton A., Hall J.E. 2001, Medical Ph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/00A61K38/00C12Q1/00
CPCG01N33/6893G01N2333/54G01N2333/8139G01N2800/347G01N2800/52G01N33/543G01N2333/46
Inventor C.E.伊拉拉扎巴尔穆诺兹
Owner UNIV DE LOS ANDES
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