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Formula and preparing method of freeze-dried excipient preparation

A technology for freeze-drying excipients and preparations, which is used in freeze-dried transportation, pharmaceutical formulations, cosmetic preparations, etc.

Active Publication Date: 2014-07-02
常州柚盾实业投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to technical limitations and traditional concepts, there are no reports in the literature that only active ingredients and binders can be used to make lyophilized excipients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Vitamin C: collagen = 100:1, vitamin C 100mg, accurately filled into a 0.3m1 mold, collagen 1mg, dissolved in 0.2ml of water, poured into a mold containing 100mg of vitamin C, stirred to disperse the water in the powder, Quick-frozen to -100 degrees Celsius, freeze-dried to become a solid drink.

Embodiment 2

[0073] Pearl powder: hyaluronic acid = 1:100, 100mg of hyaluronic acid, 90mg of hyaluronic acid mixed with 1mg of pearl fine powder, accurately filled into a 0.5ml mold, 10mg of hyaluronic acid dissolved in 0.3ml of water, poured Put it into a mold containing 90mg of hyaluronic acid and 1mg of pearl powder, stir to disperse water in the powder, freeze to -196 degrees Celsius, and freeze-dry to become a solid skin care essence.

Embodiment 3

[0075] Bilberry extract: pullulan=5:1, 60 mg of bilberry extract, 12 mg of pullulan and 0.4 ml of water are prepared into a solution, filled into a 0.4 ml mold, and freeze-dried to become a solid beverage.

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PUM

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Abstract

The invention relates to a formula and a preparing method of a freeze-dried excipient preparation. The formula is new and simplified. By controlling the ratio of an adhesive and the ratio of active components in the freeze-dried excipient preparation, the freeze-dried excipient preparation can be free of a skeleton supporting agent system and only contains the adhesive and the active components. The skeleton supporting agent comprises, but not limited to, sugar, sugar alcohol, amino acids having 2-12 carbon atoms, inorganic salts, and the like. Based on this, an antioxidant, a corrigent, essence, a skin penetration enhancer, a pH modifier, and other auxiliary materials can be added into the preparation. By avoiding the use of the skeleton supporting agent, technical effects of reducing the moisture adsorption risk, simplifying the preparing process, reducing the cost and increasing the drug loading capacity per unit are achieved.

Description

technical field [0001] The invention relates to a formulation and preparation method of a lyophilized excipient, in particular to a formulation material of the lyophilized excipient that does not contain Matrix support system, formulation and preparation method of lyophilized excipient containing only binder and active ingredient. Background technique [0002] Freeze-drying excipient technology refers to adding a skeleton support agent and a binder to a flowable liquid, semi-solid or solid active ingredient, or the flowable liquid, semi-solid or solid itself contains a binder and a skeleton The support agent is then poured into a molding mold and shaped by a freeze-drying process. The preparation prepared by the freeze-drying excipient technology is called a freeze-dried excipient preparation. Because this type of preparation adopts a freeze-drying process, which can protect heat-sensitive components from being destroyed, and at the same time produce a large number of micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K45/00A61K47/42A61K47/38A61K47/36A61K47/34A61K47/26A61K8/02A61K8/81A61K8/73A61K8/64A61K8/60
Inventor 李和伟
Owner 常州柚盾实业投资有限公司
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