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miRNAs (micro ribonucleic acids) used for detecting prostatic cancer

A prostate cancer, mir-206 technology, applied in the field of prostate cancer diagnosis, can solve problems such as prostate cancer diagnosis, classification, formulation of treatment targets and treatment plans, disease prognosis interference, unfavorable treatment, etc.

Inactive Publication Date: 2014-06-25
SHAOXING PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Therefore, miRNAs are an important tool for tumor classification, early detection, disease prognosis, formulation of treatment plans and therapeutic targets, etc. However, during the testing process, miRNAs associated with the onset of prostate cancer have not been confirmed, which makes the diagnosis of prostate cancer difficult. , classification, formulation of treatment targets and treatment plans, disease prognosis, etc. have caused serious interference, which is not conducive to treatment

Method used

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  • miRNAs (micro ribonucleic acids) used for detecting prostatic cancer
  • miRNAs (micro ribonucleic acids) used for detecting prostatic cancer
  • miRNAs (micro ribonucleic acids) used for detecting prostatic cancer

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Embodiment Construction

[0016] The present invention will be further explained below in conjunction with specific embodiments. These examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. Within the spirit of the present invention and the protection scope of the claims, any modification and change made to the present invention will fall into the protection scope of the present invention. For example, the miRNAs can also be applied to the detection of saliva, urine, serum, plasma, tear fluid, amniotic fluid and other body fluids of patients with prostate cancer. Apparently, the present invention is not limited to this embodiment, and there may be many modifications, all of which should be regarded as the protection scope of the present invention.

[0017] 1. Materials

[0018] Prostate cancer and benign prostatic hyperplasia tissue specimen collection and processing

[0019] Collected from 10 high-grade prostate cancer (G>7) sample...

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Abstract

The invention relates to miRNAs (micro ribonucleic acids) used for detecting prostatic cancer and a kit, and belongs to the technical field of molecular biology, wherein the miRNAs comprise carcinogenic miRNAs and cancer-inhibiting miRNAs; expression quantity of the carcinogenic miRNAs in real-time PCR (polymerase chain reaction) method detection, and expression quantity of the cancer-inhibiting miRNAs in the real-time PCR method detection are lowered. According to different degrees of the prostatic cancer, different carcinogenic miRNAs and cancer-inhibiting miRNAs are adopted to respectively carry out diagnosis in a targeted manner. A technical scheme provided by the invention is adopted, so that diagnosis and prognosis prediction results of the prostatic cancer can be quickly, simply, efficiently and stably obtained.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and in particular relates to the diagnosis of prostate cancer by using miRNAs. By detecting the expression of miRNAs in prostate cancer tissue and benign prostatic hyperplasia tissue as a control, prostate cancer with different degrees of malignancy can be diagnosed. Background technique [0002] In the existing research, the level of protein or mRNA of a certain gene is mostly used clinically for tumor diagnosis, prognosis analysis and tumor treatment, but thousands of proteins or mRNA need to be analyzed during the testing process, and the testing process is cumbersome; and The mRNA selected in the test process is easily degraded, and the test process is unstable. [0003] MiRNA was first discovered in nematodes in 1991. It is an endogenous non-coding RNA with a length of 18-25nt. It is relatively conservative in evolution. The target mRNA is fully or partially complementary to reco...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 宋春娇陈欢余建华徐潮阳
Owner SHAOXING PEOPLES HOSPITAL
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