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Application of saussurea involucrate culture in preparation of product for promoting bone health

A technology of snow lotus culture and bone, which is applied in the fields of application, bone disease, food preparation, etc., and can solve the problems that did not mention the independent role of snow lotus culture

Inactive Publication Date: 2014-06-25
DALIAN PRACTICAL BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In terms of anti-arthritis, the patent ZL201010519409.6 discloses that "the snow lotus culture composition has been found through experiments to be effective in preventing and alleviating arthritis", but the snow lotus culture composition given in this patent contains the following components: Snow lotus culture , cucumber seed powder, lettuce seed powder, celery seed powder, and calcium source, and the culture of snow lotus appeared to "make up for the singleness of rapeseed food on the market for arthritis health care", and did not mention the culture of snow lotus Independent role in arthritis

Method used

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  • Application of saussurea involucrate culture in preparation of product for promoting bone health
  • Application of saussurea involucrate culture in preparation of product for promoting bone health
  • Application of saussurea involucrate culture in preparation of product for promoting bone health

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] BMD (Bone Mineral Density) is a commonly used physiological index in orthopedic clinics, and is currently the standard for diagnosing osteoporosis. The World Health Organization's definition of osteoporosis is based on the T value of bone density (comparing the bone density (BMD) obtained by the examination with the BMD of the normal young population to obtain a high (+) or low (-) young age The standard deviation (SD) number of people), as follows:

[0028] Normal: bone mineral density within 1 SD of the mean for young people (T value between +1 and -1);

[0029] Low bone density: the bone density is 1-2.5 SD lower than the average value of young people (T value is between -1 and -2.5);

[0030] Osteoporosis: bone mineral density 2.5 SD lower than the mean for young people (T value lower than -2.5);

[0031] Severe osteoporosis: Bone mineral density 2.5 SD below the mean for young adults (T-score below -2.5) with one or more osteoporotic fractures.

[0032] Sample: ...

Embodiment 2

[0039] Saussurea cerevisiae culture used in clinical trials of rheumatoid arthritis

[0040] Test method: Case selection refers to the diagnostic criteria of rheumatoid arthritis of the American College of Rheumatology. The course of disease is 6 months to 11 years. After taking the culture of snow lotus, observe the patient's signs.

[0041] Number of cases: 15

[0042] Trial time: 4 weeks

[0043] Dosage: 2 times a day, 100mg sausage culture each time

[0044] Test results: Pain improved by 73.3%, swelling improved by 66.7%, and morning stiffness improved by 60.0%.

[0045] Comparison of the total effect of joint pain, swelling and morning stiffness in patients after treatment

[0046] case number

[0047] 8

experiment example 1

[0049] Drug efficacy experiment of Saussurea edulis culture in increasing bone density, increasing bone calcium content, and preventing and treating osteoporosis

[0050] Materials and Methods

[0051] Test grouping: sham operation group, model control group, positive control group (estradiol 0.12mg / kg)

[0052] Test model: ovariectomized low bone density model

[0053] Experimental animals: SD adult female rats, adapted to feeding for 3-5 days before castration.

[0054] Modeling method: Rats underwent bilateral ovariectomy to castrate, and at the same time were given special feed to form a model with low bone density; another part of the rats underwent similar operations but did not remove bilateral ovaries, only part of the fat was removed, which was a sham model. surgery group.

[0055]The formula feed was formulated with reference to the AIN93 feed formula to prepare the semi-finished feed, and the soybean-derived ingredients in the feed were replaced with appropriate ...

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Abstract

The invention discloses application of a saussurea involucrate culture in preparation of a product for promoting bone health. The application comprises preparation of a food or a drug for promoting bone health. The effect of promoting bone health is prevention and treatment of osteoporosis, improvement of the calcium content of the bone, increase of the bone mineral density, improvement of rheumatoid arthritis and treatment of arthritis. An animal test and a clinical test show that the saussurea involucrate culture can be used for improving the calcium content of the bone, and increasing the bone mineral density to prevent and treat osteoporosis, and can be used for improving the rheumatoid arthritis, so as to be applied to the food or drug for promoting bone health.

Description

technical field [0001] The invention relates to the technical fields of food and medicine, in particular to the application of snow lotus culture in preparing products for promoting bone health. Background technique [0002] Osteoporosis is a systemic bone disease characterized by low bone mass and damage to bone microarchitecture, resulting in increased bone fragility and susceptibility to fracture. It is a degenerative disease of the bones and the risk of developing it increases with age. With the extension of human life span and the arrival of aging society, osteoporosis has become an important health problem for all human beings. Osteoporosis is also a common and frequently-occurring disease that threatens menopausal women. Osteoporosis is caused by a variety of factors. Its basic pathological mechanism is the defect in the coupling of bone resorption and bone formation in the process of bone metabolism, which leads to the imbalance of calcium and phosphorus metabolism...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61P19/08A61P19/02A61P19/10A61P29/00A23L1/29A23L33/00
Inventor 刘汉石范文霞张献周术涛
Owner DALIAN PRACTICAL BIOTECH
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