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Micro-cantilever beam array biochemical sensing apparatus based on piezoelectric scanning and method

A technology of array sensing and micro-beams, which is applied in the field of biochemical sensing, can solve the problems of affecting the detection quality of spot displacement, the adjacent distance cannot be adjusted, and the detection sensitivity is not high, so as to achieve convenient and fast positioning detection, simple structure and high efficiency. Effect

Inactive Publication Date: 2014-06-18
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the adjacent distance of the emitted beams of the vertical resonator surface-emitting laser cannot be adjusted, it can only irradiate the microbeam array with a certain spacing, which is less flexible and expensive; in the CCD surface light source detection method, due to the microbeam array The bending of the beam tip will cause the image to scatter, which seriously affects the detection quality of the spot displacement, resulting in low detection sensitivity and slow speed in multi-channel detection

Method used

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  • Micro-cantilever beam array biochemical sensing apparatus based on piezoelectric scanning and method
  • Micro-cantilever beam array biochemical sensing apparatus based on piezoelectric scanning and method
  • Micro-cantilever beam array biochemical sensing apparatus based on piezoelectric scanning and method

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Embodiment 1

[0089] Example 1. Measurement of temperature changes based on piezoelectric scanning microbeam array sensing method

[0090] 1. A commercial microbeam array (German micromotive company, such as Figure 5 As shown, the microbeams are 500 μm long, 90 μm wide, and 1 μm thick, and the surface is coated with a 0.02 μm thick gold layer. Batteries, thermostats, PSDs, A / D converters, computers such as figure 1 Shown) in the biochemical reaction pool.

[0091] 2. Modification of Microbeams and Related Configuration Adoption Figure 4 The capillary array nesting modification platform shown in .

[0092] 3. Fix a convex lens with a focal length of 10cm on a piezoelectric ceramic tube and place it in front of a semiconductor laser. After the piezoelectric ceramic tube is energized, the convex lens is driven to do periodic deflection together. The converged laser beam emitted by the laser is changed by a mirror and then periodically scans two fixed points on the substrate of the microb...

Embodiment 2

[0094] Example 2. Detection of Clenbuterol by Microbeam Array Biochemical Sensing Method Based on Piezoelectric Scanning

[0095] 1. Experimental Setup and Reagents

[0096] The specific structure of the detection system figure 1 As shown in , it mainly includes a laser (parameters: diameter 8mm, length 20mm, wavelength of laser emission is 650nm, diameter of laser focus spot is 200μm), piezoelectric deflector (composed of piezoelectric ceramic tube and lens, among which piezoelectric ceramic tube The length is 30mm, the outer diameter is 6.35mm, the inner diameter is 5.35mm, the maximum input voltage is ±200V, the deflection range is ±16μm; the focal length of the lens is 10cm, fixed at the end of one end of the piezoelectric ceramic tube), biochemical reaction pool (volume 0.5mL, full Sealed, composed of a sample inlet with an inner diameter of 1mm, a sample outlet with an inner diameter of 1mm, a glass plate, and a microbeam fixing table. Figure 11 ), temperature control...

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Abstract

The present invention relates to a micro-cantilever beam array biochemical sensing apparatus. The micro-cantilever beam array biochemical sensing apparatus comprises a reaction cell, a micro-cantilever beam array, a semiconductor laser unit, a piezoelectric deflector, a signal generator, a photoelectric position sensitive detector (PSD) and a data treatment device. According to the apparatus, scanning detection of a single converged laser beam on the micro-cantilever beam array can be realized by using a piezoelectric ceramic tube to drive a convex lens fixed thereon to deflect, high-sensitivity, fast and parallel detection on biochemical reaction information of the micro-cantilever beam can be realized, and the micro-cantilever beam array biochemical sensing apparatus can be used for monitoring and detection in food safety, environmental pollution, bio-medicine, scientific researches, production manufacturing and other fields. The invention further discloses a biochemical detection method using the micro-cantilever beam array biochemical sensing apparatus.

Description

technical field [0001] The invention belongs to the technical field of biochemical sensing, and in particular relates to a microcantilever beam array biochemical sensing device and method, which can be applied to food safety, environmental pollution, biomedicine, scientific research, manufacturing and other fields. Monitoring and detection. Background technique [0002] The microcantilever (hereinafter referred to as microbeam) biochemical sensing technology based on surface stress detection is a new sensing technology that has emerged in recent years. Its principle is to immobilize the probe (antigen or antibody) molecule directly or indirectly. (Modification) on the gold-plated layer on one side of the microbeam, when the target molecules in the sample liquid to be detected react specifically with the probe molecules on the gold surface of the microbeam, the surface stress of the microbeam will change, resulting in microbeam Bending deformation, the process of detecting t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N33/577G01B11/02
CPCG01N33/54366G01N33/54373
Inventor 张青川邬林程腾
Owner UNIV OF SCI & TECH OF CHINA
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