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Glucosamine hydrochloride pellet preparation and preparation method thereof

A technology of glucosamine hydrochloride and pellets, used in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve problems such as insufficient bioavailability and limited application, and achieve good absorption kinetics reproducibility, biological The effect of high utilization and low consumption of materials

Active Publication Date: 2018-04-06
HAINAN PULIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the first-pass effect, the bioavailability of this product after oral administration is less than 30%.
This limits its application to some extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: Preparation of glucosamine hydrochloride pellets is as follows.

[0031] Preparation of glucosamine hydrochloride pills:

[0032] Glucosamine hydrochloride (particle size 50μm) 240g

[0033] Micronized silica gel 2.4g

[0034] Microcrystalline cellulose core (0.45~0.6mm) 60g

[0035] Povidone K30 (PVP K30) 12g

[0036] 95% ethanol 252.3g

[0037] Purified water 135.8g

[0038] Made 314.4g

[0039] making process

[0040] 1. Pretreatment: crush glucosamine hydrochloride to a suitable particle size, and then mix with micronized silica gel;

[0041] 2. Prepare adhesive: weigh PVP K30, dissolve in purified water, add 95% ethanol, and stir evenly;

[0042] 3. Put the microcrystalline cellulose pellet core in a centrifugal granulator, adjust the parameters, and apply the drug with the above-mentioned binder. The specific parameters are as follows:

[0043] Host: 180-250rpm;

[0044] Shotcrete: 5-25rpm;

[0045] Powder supply: 5-25rpm;

[0046] Air v...

Embodiment 2

[0071] Embodiment 2: Preparation of glucosamine hydrochloride pellets is as follows.

[0072] Preparation of glucosamine hydrochloride pills:

[0073] Glucosamine Hydrochloride 240g

[0074] Talc powder 1.2g

[0075] Simethicone 1.2g

[0076] Starch core (0.45~0.6mm) 60g

[0077] HPMC (3CP) 12g

[0078] 95% ethanol 204g

[0079] Purified water 109.6g

[0080] Made 314.4g

[0081] making process

[0082] 1. Prepare the drug solution: weigh HPMC (3CP), dissolve in purified water, add glucosamine hydrochloride, stir to dissolve; add 95% ethanol, stir; add talcum powder and simethicone, and stir evenly;

[0083] 2. Put the starch pellet core in the fluidized bed, adjust the parameters, and use the above adhesive to apply the drug. The specific parameters are as follows:

[0084] Fan: 10-25rpm;

[0085] Liquid supply: 3-12rpm;

[0086] Inlet air temperature: 35-45°C;

[0087] Material temperature: 25-35°C;

[0088] Outlet temperature: 33-37;

[0089] Atomization press...

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Abstract

The invention relates to a glucosamine hydrochloride pellet preparation and a preparation method thereof. The glucosamine hydrochloride pellet preparation uses glucosamine extracted from marine organisms as an active ingredient, and consists of glucosamine pills and a coating layer. The glucosamine pills include the following materials in weight percentage: 70-90% hydrochloric acid Glucosamine, particle size 30~100μm, 10~20% blank drug core, particle size 0.2~1mm, 2~10% binder, 0.1~1% flow aid. The glucosamine hydrochloride pellet preparation of the present invention is composed of a plurality of drug release units as a whole, and the abnormal drug release behavior of individual units does not affect the overall situation, and an ideal overall drug release rate can be obtained to achieve the expected blood drug concentration, thereby obtaining Ideal curative effect, and can reduce the irritating effect on the gastrointestinal tract.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a glucosamine hydrochloride pellet preparation for treating osteoarthritis prepared by using glucosamine extracted from shrimp and crab shells in the sea and a preparation method thereof. Background technique [0002] Glucosamine hydrochloride is a marine biological preparation, white crystal, slightly sweet, soluble in water, and is the main component of chondroitin sulfate. It can promote the synthesis of mucopolysaccharides in the human body, increase the viscosity of joint synovial fluid, improve the metabolism of articular cartilage, and benefit the repair of articular cartilage. Has obvious anti-inflammatory and analgesic effects. This product improves the metabolic function and nutrition of bone and cartilage tissue by stimulating the biochemical synthesis of mucopolysaccharides and increasing the intake of bone calcium. It can also improve and enhance the viscosity of syno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/7008A61K47/38A61K47/36A61K47/32A61P19/02A61P29/00
Inventor 范敏华孙军朱旭雷
Owner HAINAN PULIN PHARMA
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