Preparation method of magnetic temperature-sensitive nanoparticles

Abstract

The invention relates to a preparation method of magnetic temperature-sensitive nanoparticles. Aiming at the deficiencies of magnetic nanoparticles, the magnetic temperature-sensitive nanoparticles are prepared by the following steps: firstly, silylanizing the magnetic nanoparticles; and then carrying out graft polymerization, ultrasonic dispersion, washing and extraction, and vacuum drying. The preparation method is strict in process, advanced and reasonable, full and accurate in data and good in shape of products which are ash black powder particles, wherein the particle diameter of the powder is less than or equal to 220nm. The magnetic nanoparticles have remarkable superparamagnetism and a carbon wrapping layer is arranged on the surface to prevent mutual attraction among the nanoparticles in the application process to lead to coagulation. The product is remarkable in temperature-sensitive effect, high in purity which reaches 99% and high in yield which reaches 97.5%. The preparation method is a very ideal method for preparing the magnetic temperature-sensitive nanoparticles. The product can be applied to the fields such as medicines, bioengineering and various industries.

Description

technical field [0001] The invention relates to a method for preparing magnetic temperature-sensitive nanoparticles, which belongs to the technical field of preparation and application of magnetic field and temperature environment-responsive nanoparticles. Background technique [0002] Environmentally responsive nanoparticles are special functional nanoparticles that can respond quickly to special stimuli from the external environment, such as temperature, pH, ionic strength, pressure, electric field, and magnetic field. Particles; due to the unique physicochemical and colloidal properties of smart nanoparticles, they have great application value. [0003] Magnetic temperature-sensitive nanoparticles are nanoparticles with magnetic field and temperature effects, which can be easily and quickly separated from the medium under the action of an external magnetic field. Since the temperature-sensitive polymer has the lowest critical solution temperature in aqueous solution, it w...

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Problems solved by technology

[0004] At present, the preparation of magnetic temperature-sensitive nanoparticles is still in research, and there are still many shortcomings, such as complicated and cumbersome steps, the need to prepare magnetic nanoparticles in advance, and then combine with temperature-sensitive polymers; graft temperature-sensitive monomers on the surface of magnetic nanoparticles , easily lead to mutual attraction of magnetic nanoparticles and coagulation; the particle size distribution of the prepared magnetic temperature-sensitive nanoparticles is wide, which is not conducive to the application process control, which greatly limits the application of magnetic temperature-sensitive nanoparticles

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