Physalin B crystal and extraction and preparation methods as well as application of physalin B crystal in preparing anti-inflammatory medicines

Abstract

The invention discloses a physalin B crystal which belongs to a monoclinic system, wherein the space group is P2(1); the lattice parameters (i)a( / i) is equal to 12.4996 (2), (i)b( / i) is equal to 14.35620(10), (i)c( / i) is equal to 14.75190(10) and (i)beta( / i) is equal to 99.8740(10) degrees; the volume of the crystal cell is 2607.97(5)3; the crystalline density is 1.382mg / m<3>; (i)Z( / i) is equal to 4; F(000) is equal to 1152; the final departure factors (i)R1( / i) is equal to 0.0407, and (i)wR2( / i) is equal to 0.1056. The invention further discloses an extraction method of the crystal. The extraction method comprises the following steps: 1) extracting a physalis plant material to remove a solvent to obtain an extract; 2) repeatedly dissolving soluble parts of the extract by petroleum ether, standing and filtering; 3) repeatedly dissolving the extract treated by petroleum ether by ethyl acetate, standing, filtering, combining the filtrate and removing the solvent to obtain a solid; and 4) dissolving the solid, mixing a sample by silica gel, passing through a column by a dry method, carrying out gradient elution, collecting an eluant, repeatedly carrying out column chromatography, and finally, removing the solvent from the eluant. The invention further discloses an application of the physalin B crystal in preparing anti-inflammatory medicines. The crystal obtained by the invention has higher anti-inflammatory activity.

Description

technical field [0001] The invention relates to a physalis B crystal, an extraction and preparation method thereof and an application of the physalis B crystal in the preparation of anti-inflammatory drugs. Background technique [0002] Inflammatory response is one of the important defense mechanisms of the body against tissue cell damage caused by physical, chemical, immune or biological factors. It is also the basic pathological process of the occurrence and development of many diseases. Diseases (such as rheumatoid arthritis, rheumatic fever, osteoarthritis), asthma, chronic obstructive pulmonary disease, trauma, burns, endotoxic shock, Alzheimer's disease, and even heart failure all have inflammatory mediators participate. [0003] Anti-inflammatory drugs are divided into two categories: steroids (adrenocortical hormones) and non-steroidal anti-inflammatory drugs (NSAIDs). Can be divided into ① mineralocorticoids. ② glucocorticoids, etc. Glucocorticoids have extensiv...

AI Technical Summary

Problems solved by technology

④ Long-term application can cause high blood pressure and atherosclerosis; ⑤ Cause osteoporosis, muscle atrophy, and slow wound healing

⑥ long-term use of such drugs will lead to dependence

[0006] At present, because the pathogenesis of inflammation is not completely clear, the adverse reactions caused by long-term drug treatment also bring pain to patients.

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