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Vasospasm preventing nanometer fiber membrane and preparing method thereof

A nanofibrous membrane and vasospasm technology, applied in the field of biomedicine, can solve problems such as difficulty in ensuring continuous drug dosage, affecting normal organs or tissues, frequent injection of blood vessels, etc., to achieve prevention and treatment of vasospasm, flexibility and stretchability Good, good biodegradability effect

Active Publication Date: 2014-04-30
海南德拉米克投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, when injecting papaverine into the body, there are the following problems: (1) The drug utilization rate at the vascular site is low; (2) Systemic administration affects other normal organs or tissues; (3) It is difficult to ensure the continuous drug amount required locally ;(4) Does not protect the surgical suture site; (5) Frequent injections; (6) Vascular blockage and local sclerosis; (7) Repeated physical pain for patients
Therefore, there is still a gap in the research on the manufacture of implantable papaverine sustained-release preparations

Method used

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  • Vasospasm preventing nanometer fiber membrane and preparing method thereof
  • Vasospasm preventing nanometer fiber membrane and preparing method thereof
  • Vasospasm preventing nanometer fiber membrane and preparing method thereof

Examples

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preparation example Construction

[0037] In the present invention, the preparation method of the degradable membrane carrier preferably includes:

[0038] The degradable material is dissolved in an organic solvent to prepare a degradable material solution, and then electrospun to prepare the degradable membrane carrier.

[0039]In the present invention, the types of the degradable material and the organic solvent are consistent with the types of the degradable material and the organic solvent described in the above technical solution, and will not be repeated here; the mass ratio of the degradable material to the organic solvent is preferably 1:2-20, more preferably 1:1:4-15, most preferably 1:6-10. In the present invention, the temperature of the electrospinning is preferably 0°C to 35°C, more preferably 15°C to 30°C, most preferably 20°C to 25°C; the flow rate of the electrospinning is preferably 0.3mL / h~0.8mL / h, more preferably 0.4mL / h~0.7mL / h, most preferably 0.5mL / h~0.6mL / h; the voltage of the electrosp...

Embodiment 1

[0070] 0g, 0.1111g, 0.25g, 0.4285g, 0.6666g and 1g of polyethylene glycol (PEG) were mixed with 1g of poly(L-lactic acid) (PLLA) respectively to obtain PLLA-PEG in different mass ratios;

[0071] Dissolving the above-mentioned PLLA-PEG in different mass ratios in a mixed solution of 2 g dimethylformamide and 4 g methylene chloride to obtain PLLA-PEG solutions in different mass ratios;

[0072] Dissolve 0.06g papaverine hydrochloride in 0.5mL hexafluoroisopropanol and then dissolve it in the above-mentioned PLLA-PEG solutions with different mass ratios to obtain the electrospinning solution, which are named PLLA and PLLA respectively according to the mass ratios of PLLA and PEG. -10%, PLLA-20%, PLLA-30%, PLLA-40% and PLLA-50%;

[0073] Set the voltage in the electrospinning technical parameters to 10KV, the flow rate to 0.5mL / min, the distance from the needle to the collecting plate to 15cm, the temperature to 25°C, and the relative humidity to 50%. The above obtained PLLA, PLL...

Embodiment 2

[0108]0g, 0.1111g, 0.25g, 0.4285g, 0.6666g and 1g of polyethylene glycol (PEG) were mixed with 1g of poly(L-lactic acid) (PLLA) respectively to obtain PLLA-PEG in different mass ratios;

[0109] Dissolving the above-mentioned PLLA-PEG with different mass ratios in a mixed solution of 2g tetrahydrofuran and 4g chloroform to obtain PLLA-PEG solutions with different mass ratios;

[0110] Dissolve 0.9g of papaverine hydrochloride in 0.5mL of ethanol and then dissolve it in the PLLA-PEG solutions with different mass ratios above to obtain the electrospinning solution, which are respectively named PLLA, PLLA-10%, PLLA-20%, PLLA-30%, PLLA-40% and PLLA-50%;

[0111] Set the voltage in the electrospinning technical parameters to 50KV, the flow rate to 0.5mL / min, the distance from the needle to the collecting plate to 15cm, the temperature to 35°C, and the relative humidity to 50%. The above obtained PLLA, PLLA-10%, PLLA- 20%, PLLA-30%, PLLA-40% and PLLA-50% electrospinning solutions w...

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Abstract

The invention provides a nanometer fiber membrane. The nanometer fiber membrane comprises a degradable membrane carrier and a vasospasm resisting drug which is doped in the degradable membrane carrier, wherein the degradable membrane carrier is made of degradable materials. The nanometer fiber membrane which is provided by the invention comprises the vasospasm resisting drug, the vasospasm resisting drug which is doped in the degradable membrane carrier can be well attached and matched with a vessel as a sustained release drug of the implantable vasospasm resisting drug to prevent and treat vasospasm, the utilizing rate of the drug required for a part is high, and the frequent intramuscular administration of the vasospasm resisting drug is not needed. The nanometer fiber membrane is degradable, and the release speed of the vasospasm resisting drug is controlled through the control of the degrading speed of the degradable membrane carrier. Besides, the biodegradability of the nanometer fiber membrane is great, no fiber materials are left in the body after degrading, and no cell toxicity, inflammation reaction or tissue proliferation occurs. The nanometer fiber membrane has great flexibility and tensile performance, can resist extrusion and stretching in the vascular repair process and is suitable for supporting cell growth or drug delivery.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an anti-vasospasm nanofibrous membrane and a preparation method thereof. Background technique [0002] Microsurgery is a discipline that studies the use of optical magnification equipment and microsurgical equipment to perform fine surgery; it is a discipline that develops relatively rapidly in my country's clinical medicine and has a very important position. Various advanced microsurgical techniques are widely used throughout the country. Spread, the success rate of microsurgery is also rising. However, microsurgery will be accompanied by complications, and the occurrence of complications often leads to serious consequences, especially in microvascular surgery, once the blood vessels are no longer smooth, it will definitely cause ischemia, hypoxia and even necrosis of limb tissues. Among the complications of microvascular surgery, vasospasm is one of the relative...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/14
Inventor 崔文国潘国庆范存义刘生和刘珅
Owner 海南德拉米克投资有限公司
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