Traditional Chinese medicine composition for treating aseptic necrosis of femoral head and preparation method thereof

A technology for aseptic necrosis and composition is applied to a traditional Chinese medicine composition for treating aseptic necrosis of the femoral head. Inconvenient monitoring of drug concentration and other problems, to achieve the effect of promoting bone regeneration of femoral head and relieving ischemic pain of femoral head

Inactive Publication Date: 2014-04-23
曹玮 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the inconvenient monitoring of blood drug concentration of anti-hypercoagulant and low-fibrinolytic drugs, the clinical application of western medicine in the treatment of aseptic necrosis of the femoral head is not standardized, and the curative effect is difficult to guarantee

Method used

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  • Traditional Chinese medicine composition for treating aseptic necrosis of femoral head and preparation method thereof

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preparation example Construction

[0034] The preparation method of capsule preparation of the present invention, specifically carries out according to the following steps:

[0035] Step 1: Weigh 5%-10% Cork Phellodendron, 5%-10% Paeoniae Cortex, 5%-10% Achyranthes bidentata, 5%-10% Hanfangji, 5%-10% betel nut, and Atractylodes atractylodes according to the mass percentage. 3%-7%, Salvia miltiorrhiza 25%-40%, Liuxingzi 5%-10%, Corydalis 5%-10%, Raw licorice 3%-7%, the total content of the above components is 100%, and the above The medicines are all washed and dried after removing impurities;

[0036] Step 2, fully mix the above-mentioned medicines treated in step 1, add 8-10 times the amount of water to soak for 2-3 hours, heat and decoct for 1.5-2 hours, filter, add 6-8 times the amount of water to the medicinal residues, and heat Decoct for 1-1.5 hours, filter, and combine the filtrates to obtain the supernatant; the supernatant is concentrated to a relative density of 1.05-1.06, and then enters the spray d...

Embodiment 1

[0041]Take each crude drug by the following mass percentages: Cortex Phellodendri 8%, Cortex Paeonol 8%, Rhizoma Achyranthes Radix 7%, Han Fang 7%, Areca 7%, Atractylodes Rhizoma 7%, Salvia miltiorrhiza 32%, Rhizoma 8%, Corydalis 9%, raw licorice 7%, the total content of the above components is 100%, and the above drugs are all cleaned and dried after removing impurities;

[0042] Then add 10 times the amount of water to soak for 2 hours, heat and decoct for 2 hours, filter, add 8 times the amount of water to the drug dregs, heat and decoct for 1.5 hours, filter, combine the filtrates, and separate the solids , to obtain the supernatant; the supernatant is concentrated to a relative density of 1.06, and enters the spray dryer, the inlet air temperature is controlled at 150°C, the outlet air temperature is 105°C, the atomizer speed is 60 rpm, and the feed rate is 5ml / min , to obtain a spray-dried powder, which can be crushed and sieved to obtain a fine powder. The above-mentio...

Embodiment 2

[0044] Take each crude drug by the following mass percentages: Phellodendron 5%, Cortex paeonol 10%, Achyranthes bidentata 5%, Hanfang 10%, Betel nut 5%, Atractylodes atractylodes 7%, Salvia miltiorrhiza 40%, Rhizoma 5%, Corydalis 10%, raw licorice 3%, the total content of the above components is 100%, and the above drugs are all cleaned and dried after removing impurities;

[0045] Then add 9 times the amount of water to soak the above-mentioned medicines according to the mass percentage, soak for 3 hours, heat and decoct for 2 hours, filter, add 6 times the amount of water to the dregs, heat and decoct for 1.2 hours, filter, combine the filtrates, and separate the solids , to obtain the supernatant; the supernatant is concentrated to a relative density of 1.05, and enters the spray dryer, the inlet air temperature is controlled at 160°C, the outlet air temperature is 100°C, the atomizer speed is 60 rpm, and the feed rate is 6ml / min , to obtain a spray-dried powder, which can...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating aseptic necrosis of femoral head and a preparation method thereof. The traditional Chinese medicine composition comprises the effective components by mass: 5-10% of phellodendron, 5-10% of cortex moutan, 5-10% of medicinal cyathula root, 5-10% of fourstamen stephania root, 5-10% of betel nut, 3-7% of atractylodes, 25-40% of red sage root, 5-10% of cowherb seed, 5-10% of corydalis tuber and 3-7% of raw liquorice. Under the guidance of theory of traditional Chinese medicine, the traditional Chinese medicine composition disclosed by the invention aims to improve the microcirculation of the femoral head; the composition has the efficacies of adjusting qi and blood, relaxing muscles and activating blood, expelling stasis and stopping pain, removing necrotic tissue and promoting tissue regeneration and plays the roles of relieving the femoral head ischemic pain and promoting the bone regeneration of the femoral head.

Description

technical field [0001] The invention belongs to the technical field of preparation of Chinese patent medicines, and relates to a traditional Chinese medicine composition for treating aseptic necrosis of the femoral head, and also relates to a preparation method of the traditional Chinese medicine composition. Background technique [0002] Aseptic necrosis of the femoral head is a lesion in which the local blood supply of the femoral head is poor due to various reasons, resulting in further ischemia, necrosis of bone cells, fracture of bone trabeculae, and collapse of the femoral head. According to incomplete statistics, there are currently 30 million people with necrosis of the femoral head in the world, and about 4 million people in my country. Femoral head necrosis can occur at any age, but it is most common in the age group of 31-60. There is no gender difference. At first, it usually manifests as dull pain or dull pain in the hip joint or its surrounding joints, which ag...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61P19/08A61P29/00
Inventor 曹玮刘艳张洪新卢强张聚良
Owner 曹玮
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