Preparation method for microcapsules with magnetic nanoparticles-containing capsule walls

Abstract

The invention relates to a preparation method for microcapsules with magnetic nanoparticles-containing capsule walls. The microcapsules are medicine-carried microcapsules which take cross-linked films of sulfydryl-containing amino acid or peptide-modified magnetic nanoparticles as capsule walls and take an oil phase loaded with hydrophobic medicines as a core material. According to the preparation method, the magnetic nanoparticles are directly loaded on the capsule walls of the microcapsules, so that the agglomeration of the magnetic nanoparticles is avoided; the magnetic nanoparticles are uniformly distributed on the capsule walls of the microcapsules, so that the contact between the magnetic nanoparticles and the medicines loaded in capsule cores is reduced to the maximum; therefore, the influence on the medicine effect and the targeting caused by the magnetic nanoparticles is reduced; the controllable targeting transmission of the medicines is realized by utilizing the magnetic targeting of the magnetic nanoparticles; the controllable targeting release of the medicines is realized by utilizing the reduction responsiveness of disulfide bonds; the preparation method is easy to operate, efficient and quick, and moreover, impurities are not easily introduced.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a preparation method of a microcapsule whose capsule wall contains magnetic nanoparticles. Background technique [0002] Microcapsules are micro-containers or packages with a specific geometric structure composed of capsule-forming substances. Due to their special structure, variability in performance and wide range of applications, they are widely used in the fields of agriculture, food and biomedicine. Significant application. There are various materials for preparing microcapsules, mainly natural polymer materials (proteins, lipids, etc.) or synthetic polymer materials (PMMA, polylactic acid, etc.), or inorganic compounds (SiO 2 , CaCO 3 Wait). Among them, natural polymer materials have important application value in the preparation of microcapsules due to their good biocompatibility, non-toxicity and easy degradation. There are many methods for preparing microcapsules. According t...

AI Technical Summary

Problems solved by technology

The preparation of magnetic microcapsules has been reported, either by introducing magnetic substances into the capsule wall by layer-by-layer self-assembly, or by directly embedding magnetic substances in the capsule core material by sonochemical methods. However, the preparation process of the former It is more complicated. Although the preparation method of the latter is simple, the magnetic substance may interact with the drug in the capsule core, directly affecting the drug efficacy and the targeting of the magnetic substance.