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Microarray sample application device

A sample spotting device and microarray technology, which is applied in the field of microarray spotting devices, can solve problems such as complex devices, small sample storage capacity, and substrate surface damage, and achieve the effects of simple operation, easy construction, and large sample storage capacity

Active Publication Date: 2014-04-09
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The contact microarray preparation will cause damage to the spotting needle and the surface of the substrate to be sampled at the same time; the non-contact microarray preparation can avoid the above problems, but the device is generally more complicated, and each sample or The sample storage capacity is small, and it is necessary to replenish samples when there are many sample points

Method used

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Embodiment Construction

[0033] The specific implementation manners of the present invention will be described in detail below in conjunction with the accompanying drawings and typical embodiments. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0034] Such as figure 1 As shown, a microarray spotting device proposed by the present invention is composed of a bottom plate 1 , a spotting unit 2 , a substrate fixing adjustment unit 3 , and a trace sample storage and delivery unit 4 .

[0035] The sampling unit 2 includes a sampling needle 5 and a fixing and adjusting mechanism for the sampling needle. Wherein, the sampling needle fixing adjustment mechanism consists of a vertical rod 6 fixed on the base plate 1, a shaft 7 fixed on the vertical rod, a cross rod 8 capable of rotating around the shaft 7, and a vertical rod 6 fixed on the vertical rod 6. The limiting part 9 is formed. The limiting component 9 limits th...

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Abstract

The invention provides a microarray sample application device, which comprises a sample application unit, a substrate fixing and adjusting unit, and a trace sample storage and delivery unit. The microarray sample application device is easy to construct, simple and convenient to operate, and can prepare various addressable microdot arrays and microstrip arrays. A sample application needle and a to-be-applied sample substrate are not damaged due to no contact, and the microarray sample application device is especially suitable for producing a sensing membrane chip, with nanoscale thickness, for surface plasma resonance imaging.

Description

technical field [0001] The invention relates to a sample spotting device, in particular to a microarray spotting device. Background technique [0002] Microarray-based chip analysis technology can achieve high-throughput detection or screening. Its chips have developed from the original DNA chip to protein chips, cell chips, tissue chips, etc., and its detection methods have developed from fluorescence imaging to label-free surface plasmons. It has broad application prospects in omics research, disease diagnosis, drug screening and other fields. Therefore, the micro-array preparation technology has also been continuously developed, which can be mainly divided into contact and non-contact. The contact microarray preparation will cause damage to the spotting needle and the surface of the substrate to be sampled at the same time; the non-contact microarray preparation can avoid the above problems, but the device is generally more complicated, and each sample or The sample sto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/55
Inventor 许吉英陈义
Owner INST OF CHEM CHINESE ACAD OF SCI
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