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Traditional Chinese medicinal preparation for preventing radiation side reactions of nasopharynx cancer chemoradiotherapy

A traditional Chinese medicine preparation, radiochemotherapy technology, applied in the field of traditional Chinese medicine preparations for preventing radiotherapy and chemotherapy side effects of nasopharyngeal carcinoma, can solve the problems of affecting the curative effect, increasing radiotherapy toxicity, increasing radiotherapy mucosal damage, etc., and achieving good curative effect and no toxic side effects. Effect

Active Publication Date: 2014-04-02
JIANGSU JIELE MEDICAL DRESSING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the curative effect of concurrent chemotherapy and radiotherapy is certain, the correlation and the increase of radiotherapy toxicity are also certain. Due to the increase of acute toxicity, the unplanned interruption of radiotherapy often affects the curative effect. At the same time, the additive effect of drug toxicity also affects the quality of life of patients, especially Although precise radiotherapy can reduce the damage of high-risk organs at present, the mucosal damage of radiotherapy increases due to the dose relationship, especially the operability of simultaneous radiochemical treatment for stage III / IV nasopharyngeal carcinoma is affected by the addition of chemotherapy.

Method used

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  • Traditional Chinese medicinal preparation for preventing radiation side reactions of nasopharynx cancer chemoradiotherapy
  • Traditional Chinese medicinal preparation for preventing radiation side reactions of nasopharynx cancer chemoradiotherapy
  • Traditional Chinese medicinal preparation for preventing radiation side reactions of nasopharynx cancer chemoradiotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Embodiment 1 oral liquid 1

[0083] 35g Shegan, 60g Coptidis Rhizoma, 30g Houttuynia cordata, 35g Zhimu, 30g Zhuru, 40g Agrimony, 40g Chrysanthemum, 30g Wintersweet, 30g Mulan, 35g Oxtail, 30g Goosegrass, 35g Baijiu, Yuanbao 20g of grass, 30g of cat's claw, 30g of celery and 20g of honeysuckle were respectively crushed and mixed to obtain a mixture, added 3.8kg of water, soaked for 5 hours and then distilled for 5 hours to collect volatile oil, medicine dregs for later use, add 60g of Acanthopanax , Codonopsis 75g, Ligustrum lucidum 50g, coix seed 30g, dendrobium 35g, madder 35g, angelica 25g, red peony 35g, curcuma 30g, selaginella 35g, heterophylla 40g, uncaria 35g, yam 25g, rhubarb 25g, jujube 25g, Cuscuta 35g, Blue Buzheng 45g, Polygonatum 35g, and Sangjisheng 25g were crushed respectively, put into the continuous extraction tank, then added the medicinal residue obtained above, added 4kg of water to extract for 5 hours, filtered the extract, and concentrated to rel...

Embodiment 2

[0084] Embodiment 2 oral liquid 2

[0085] Shegan 40g, Coptidis 65g, Houttuynia cordata 35g, Anemarrhena 40g, Zhuru 35g, Agrimony 45g, Chrysanthemum 40g, Wintersweet 30g, Mulan 30g, Oxtail 35g, Goosegrass 30g, Liquor grass 35g, Yuanbao 20g of grass, 35g of cat's claw, 35g of celery and 25g of honeysuckle were respectively crushed and mixed to obtain a mixture, added 4kg of water, soaked for 5 hours and then distilled for 5 hours to collect the volatile oil, and the dregs for later use. Add 65g of Acanthopanax, Codonopsis 80g, Ligustrum lucidum 55g, coix seed 35g, dendrobium 40g, madder 40g, angelica 25g, red peony 35g, curcuma 30g, selaginella 35g, heterophylla 40g, uncaria 35g, yam 25g, rhubarb 25g, jujube 25g , Cuscuta 35g, blue cloth 45g, Polygonatum 35g, Sangjisheng 25g were crushed respectively, put into the continuous extraction tank, then add the medicinal residues obtained above, add 4kg of water to extract for 5 hours, filter the extract, and concentrate to a relative...

Embodiment 3

[0086] Embodiment 3 oral liquid 3

[0087]Shegan 35g, Coptidis 60g, Houttuynia cordata 30g, Anemarrhena 35g, Zhuru 30g, Agrimony 40g, Chrysanthemum 35g, Wintersweet 25g, Mulan 25g, Oxtail 30g, Goosegrass 25g, Liquor grass 30g, Yuanbao 15g grass, 30g cat's claw, 30g celery and 20g honeysuckle were crushed and mixed to obtain a mixture, added 3.8kg of water, soaked for 5 hours and then distilled for 5 hours, collected volatile oil, dregs for later use, added 60g of Acanthopanax , Codonopsis 75g, Ligustrum lucidum 50g, coix seed 30g, dendrobium 35g, madder 35g, angelica 20g, red peony 30g, curcuma 25g, selaginella 30g, heterophylla 35g, uncaria 30g, yam 20g, rhubarb 20g, jujube 20g, 30g of dodder, 40g of blue cloth, 30g of Polygonatum, and 20g of Sangjisheng were crushed respectively, put into the continuous extraction tank, then added the medicinal residue obtained above, added 4kg of water to extract for 5 hours, filtered the extract, and concentrated to relative density 1.10 ...

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Abstract

The invention provides a traditional Chinese medicinal preparation for preventing radiation side reactions of nasopharynx cancer chemoradiotherapy. The traditional Chinese medicinal comprises the following raw drugs: acanthopanax, dangshen, glossy privet fruit, rhizoma belamcandae, coix seed, caulis dendrobii, rhizoma coptidis, cordate houttuynia, rhizoma anemarrhenae, radix rubiae, bamboo shavings, herba agrimoniae, angelica, radix paeoniae rubra, chrysanthemum, rhizoma zedoariae, selaginella, pseudostellaria root, uncaria, Chinese yam, Chimonanthus nitens, indigofera tinctoria, meadow fescue, eleusine indica, conyza japonica, hypericum sampsonii hance, rhubarb, Chinese date, dodder, aleppo avens, sealwort, ternate buttercup root, loranthus parasiticus, cryptotaenia japonica and honeysuckle stem. The traditional Chinese medicinal preparation is good in the curative effect and free from toxic or side effects, can be used as auxiliary therapeutic drug for the nasopharynx cancer chemoradiotherapy synchronously and used with the chemoradiotherapy for a nasopharynx cancer patient, has great advantages of enhancing the curative effect of chemoradiotherapy, relieves the side reactions after the chemoradiotherapy and improving the quality of life, and meanwhile, displays a good prospect for comprehensive treatment of the malignant tumor.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for preventing nasopharyngeal cancer radiotherapy and chemotherapy radiation side effects. Background technique [0002] Nasopharyngeal carcinoma is a high incidence of head and neck tumors in southern my country and Asian Chinese. The etiology is related to factors such as Epstein-Barr virus infection, genetics, and environmental pollution. Radiation therapy is currently the first choice for effective treatment. The 5-10-year survival rate of nasopharyngeal carcinoma patients treated with single radiotherapy is only about 40%. The treatment of stage III / IV nasopharyngeal carcinoma has become a standard method to improve the curative effect. At present, platinum-based drug combination therapy is mostly used. The combination of radiotherapy and chemotherapy can improve the survival rate, reduce local recurrence and re...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P11/02A61P11/04A61P35/00
Inventor 陈朝晖闫莉
Owner JIANGSU JIELE MEDICAL DRESSING
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