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Trandolapril dispersion pharmaceutical composition

A technology of trandolapril and its composition, which is applied in the field of rapidly dispersed trandolapril pharmaceutical composition and its preparation, and achieves the effects of good stability, stable product quality, and simple and easy method

Inactive Publication Date: 2014-03-26
TIANJIN SONGRUI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Creatinine clearance <30mL / min in patients with renal impairment or liver cirrhosis

Method used

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  • Trandolapril dispersion pharmaceutical composition
  • Trandolapril dispersion pharmaceutical composition
  • Trandolapril dispersion pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Every 1000 described trandolapril pharmaceutical compositions, its formula consists of:

[0037]

[0038]

[0039] Process steps:

[0040] 1) Preparation and processing of raw and auxiliary materials: pass trandolapril through an 80-mesh sieve for later use;

[0041] 2) Weighing and mixing: According to the prescription amount, the feeding amount is calculated by double checking; weigh the above raw and auxiliary materials respectively;

[0042] 3) mixing: mixing the prescription amount of trandolapril with the auxiliary materials except magnesium stearate, so that it is fully mixed;

[0043] 4) Granulation: Add 3% polyvinylpyrrolidone 95% ethanol solution to the uniformly mixed material to obtain a soft material with suitable hardness, and use a 30-mesh screen to granulate;

[0044] 5) Drying: Dry the prepared granules at 50°C±5°C until the water content is acceptable;

[0045] 6) Grain sizing: the dried granules are sieved with a 30-mesh sieve;

[0046] 7) T...

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Abstract

The invention relates to a drug in the field of medicines and particularly relates to a rapidly-dispersed trandolapril dispersion pharmaceutical composition and a preparation method thereof. The rapidly-dispersed trandolapril dispersion pharmaceutical composition is characterized in that every 1000 tablets of trandolapril pharmaceutical composition comprises trandolapril, lactose, pregelatinized starch, sodium cross-linked crboxymethyl cellulose and magnesium stearate. The rapidly-dispersed trandolapril dispersion pharmaceutical composition prepared by the invention is good in stability, easy to implement, capable of realizing industrialization and remarkable in economic benefit.

Description

technical field [0001] The invention relates to medicines in the field of medicine, in particular to a rapidly dispersed trandolapril pharmaceutical composition and a preparation method thereof. Background technique [0002] At present, the number of hypertensive patients in my country has exceeded 150 million, accounting for 11% of the total population. Hypertensive patients must take medicine for life and insist on taking it every day. With the development of population aging trend, the increasing pressure of social competition will affect human health. Influenced by the current situation, the surge of obese and hyperlipidemia population will reach an unprecedented number of hypertensive patients. my country's antihypertensive drug market has also been on the rise in the past few years. According to the statistics of relevant departments, in 2003, the total domestic sales of antihypertensive drugs in my country was 5.3 billion yuan, and in 2004 it was 10 billion yuan. In 20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K9/20A61K47/38A61P9/10A61P9/12
Inventor 张昊
Owner TIANJIN SONGRUI MEDICAL TECH
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