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Preparation method of amide alginate medical dressing

The technology of alginic acid amide and propylene glycol alginate is applied in the fields of medical science, absorbent pads, bandages, etc., which can solve the problems of inconvenient use and easy breakage, and achieve the effects of improving safety, low cost and strong blocking effect.

Inactive Publication Date: 2014-03-12
戴建英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to overcome the shortcomings of general alginate medical dressings which are easily broken and inconvenient to use, and provides a preparation method of alginic acid amide medical dressings with stable performance and not easy to break

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dissolve 6.0 g of propylene glycol alginate in deionized water and start stirring until the propylene glycol alginate is completely dissolved to form component A with a concentration of 2 wt%. According to the molar ratio of propylene glycol alginate and ethylenediamine is 1:1, take ethylenediamine, dissolve ethylenediamine in deionized water, and form B component with a concentration of 2wt%. Slowly add component B to component A, stir well, and place it at room temperature for 8 hours to form a hydrogel. The hydrogel was impregnated with 3 times the amount of deionized water, the water was changed every 2 hours, and washed three times in a row. The hydrogel is coated on the release paper coated with silica gel, pasted with a PU film to prepare a hydrogel dressing, and then sterilized by radiation to make a product.

Embodiment 2

[0029] Dissolve 6.0 g of propylene glycol alginate in deionized water and start stirring until the propylene glycol alginate is completely dissolved to form component A with a concentration of 1 wt%. According to the molar ratio of propylene glycol alginate and propylene diamine being 0.8:1, propylene diamine was taken, and propylene diamine was dissolved in deionized water to form component B with a concentration of 1 wt%. Slowly add component B to component A, stir well, and place it at room temperature for 8 hours to form a hydrogel. The hydrogel was impregnated with 3 times the amount of deionized water, the water was changed every 1 hour, and washed four times in a row. The hydrogel is injected into a mold to form it, put it in a refrigerator at minus 20 degrees to pre-freeze, and then put it in a freeze dryer to freeze-dry it to make an alginate amide sponge dressing, and then sterilize it to make a product.

Embodiment 3

[0031] Dissolve 6.0 g of propylene glycol alginate in deionized water and start stirring until the propylene glycol alginate is completely dissolved to form component A with a concentration of 3 wt%. According to the mol ratio of propylene glycol alginate and chitosan is 1.2:1 to get chitosan, the degree of deacetylation of the selected chitosan is 85%, and chitosan is dissolved in aqueous acetic acid to form a concentration of 3wt%. B component. Slowly add component B to component A, stir well, and place it at room temperature for 8 hours to form a hydrogel. The hydrogel was impregnated with 3 times the amount of deionized water, and the water was changed every 1.5 hours for five consecutive washes. The hydrogel is coated on the release paper coated with silica gel, pasted with a PU film to prepare a hydrogel dressing, and then sterilized by radiation to make a product.

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PUM

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Abstract

The invention discloses a preparation method of an amide alginate medical dressing, which comprises the following steps: mixing a propylene glycol alginate solution used as a component A and a polyamine compound solution or chitosan acetic acid solution used as a component B to react to generate an amide alginate aquogel, and forming the aquogel to obtain the medical dressing. The method overcomes the defects of high breaking tendency and inconvenience in use in the common alginate medical dressing; the prepared amide alginate medical dressing is more stable after swelling due to water absorption; and the aquogel formed after water absorption has a strong plugging effect on the wound surface, can not break up due to water absorption, and is convenient for medical personnel to operate.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a preparation method of alginic acid amide medical dressings. Background technique [0002] Alginic acid can be combined with different metal ions to form salts. The sodium, potassium, and ammonium salts of alginic acid are water-soluble. Except for magnesium alginate, the salts formed by alginic acid and divalent metal ions are all insoluble in water. When the valent metal ion is used as a coagulant, the water-soluble alginate can be made into an alginate sponge through a certain procedure. [0003] The water-insoluble salts of alginic acid and divalent metal ions (excluding magnesium ions) are formed by ionic bonds in which sodium ions exchange with metal ions when in contact with blood or body fluid exudates Reaction, water-soluble sodium alginate is regenerated, which promotes wound healing to a certain extent, but the integrity of the dressing is quickly destroyed...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08L5/08C08B37/04C08J9/28A61L15/28A61L15/42
Inventor 王春正戴建英
Owner 戴建英
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