Traditional Chinese medicine formula extract for treating hepatitis B and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine formula extract for treating hepatitis B and a preparation method thereof and belongs to the technical field of CO2 supercritical extraction. The raw materials of the formula extract disclosed by the invention comprise schisandra chinensis, glossy privet fruit, fructus forsythiae, sonchus brachyotus, ganoderma lucidum spore powder and curcuma zedoary. The method disclosed by the invention comprises the following steps: performing crushing, sieving, ethyl alcohol-aqueous solution soaking and supercritical extraction on schisandra chinensis, glossy privet fruit, fructus forsythiae and sonchus brachyotus to obtain a schisandra chinensis extract, a glossy privet fruit extract, a fructus forsythiae extract and a sonchus brachyotus extract, performing superfine powder wall-breaking and granulation on ganoderma lucidum spore powder, and then performing supercritical extraction to obtain a ganoderma lucidum spore powder extract, then performing crushing, aqueous solution soaking and distillation on curcuma zedoary to obtain curcuma zedoary volatile oil. The contents of the effective ingredients of the formula extract obtained by the method disclosed by the invention can be kept at a high level; the formula extract can be applied to treatment on hepatitis B and has high medicinal value.

Description

technical field [0001] An extract of traditional Chinese medicine prescription for treating hepatitis B and its preparation method, belonging to CO 2 Supercritical extraction technology field. Background technique [0002] Chinese patent CN1759884A discloses a prescription of traditional Chinese medicine for treating hepatitis B and its preparation process, which provides a compound tablet, capsule, granule and its prescription for the symptoms of hepatitis B deficiency of liver, spleen and kidney, stasis, heat, evil and poison and preparation process. However, its preparation process is as follows: ethanol extraction of schisandra, Ligustrum lucidum, and forsythia, the extract is filtered and concentrated; Beibaijiang is decocted in water and ethanol-precipitated, and the supernatant is concentrated into an extract; Fine clathrate; mix the extract and Ganoderma lucidum spore powder, add hypromellose and calcium hydrogen phosphate, granulate with ethanol, dry the granules,...

AI Technical Summary

Problems solved by technology

In the extraction of the composition, first of all, due to the different control conditions of the components extracted in the composition and the different volatilities of the active ingredients to be obtained, the extraction methods used are relatively complicated.

Especially in the supercritical extraction of each component in the composition, if the components are extracted separately, the conditions of the supercritical extraction of each component are different, and the supercritical extraction conditions of the prior art cannot obtain the extraction with higher active ingredient content. If the raw materials of each component are directly mixed and then extracted, there are many types of active ingredients in the extraction, and it is difficult to determine a reasonable extraction condition

Secondly, although pre-soaking the raw materials of the prescription extracts with ethanol-water solution can improve the extraction rate of active ingredients, the applicant has found through research that the ethanol used to soak Schisandra chinensis, Ligustrum lucidum, Forsythia, and Chives in the prior art - The concentration of the aqueous solution is unreasonably set, resulting in the ethanol-water solution not being able to achieve the best solubility of the active ingredients in Schisandra, Ligustrum lucidum, Forsythia, and Chives, which will adversely affect the subsequent supercritical extraction