Three-dimensional biological material forming equipment and extrusion nozzles thereof

Abstract

The invention discloses three-dimensional biological material forming equipment and extrusion nozzles thereof. The three-dimensional biological material forming equipment is characterized by comprising material extrusion drive units and before-extrusion temperature control units, wherein the before-extrusion temperature control units comprise heat conduction sleeves, heating bodies and semiconductor refrigeration systems; the semiconductor refrigeration systems comprise semiconductor refrigeration plates; the heat conduction sleeves are used for fixing syringes filled with biological materials; after the heat conduction sleeves fix syringes, the inner surfaces of the heat conduction sleeves are contacted with container walls of the syringes; the heating bodies are in heat conduction connection with the heat conduction sleeves; the semiconductor refrigeration plates are fixed on the outer surfaces of the heat conduction sleeves, and cold effect surfaces are tightly attached to the heat conduction sleeves; the material extrusion drive units are used for pushing pistons of the syringes fixed in the heat conduction sleeves so as to extrude the biological materials in the syringes. Compared with the prior art, a better forming effect can be obtained.

Description

technical field [0001] The invention relates to biomanufacturing technology and three-dimensional printing of biomaterials, in particular to three-dimensional forming equipment of biomaterials and extrusion nozzles thereof. Background technique [0002] Three-dimensional bioprinting or rapid prototyping of biomaterials is to extrude or spray biomaterials or cells into a special forming environment, and use layer-by-layer manufacturing to manufacture tissue engineering scaffolds or three-dimensional cell structures. In this technology, the nozzle for extrusion or injection of biomaterials is a key component. Biomaterials can generally be configured into solutions or sols. Liquid biomaterial solutions are extruded or sprayed under the action of compressed gas, piston push, screw extrusion, or piezoelectric crystals. Under special circumstances (such as cooling and containing The medium environment of the crosslinking agent, etc.) solidifies or cures. [0003] The forming env...

AI Technical Summary

Problems solved by technology

However, the existing three-dimensional forming technology of biomaterials still has a small temperature control range of the material, and can only be heated to a temperature higher than room temperature, which limits the viscosity adjustment range of the material, resulting in unsatisfactory forming effect

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