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Traditional Chinese medicine preparation for preventing and treating radioactive mucositis

A technology for traditional Chinese medicine preparations and mucositis, applied in the field of traditional Chinese medicine preparations for preventing and treating radiation mucositis, can solve problems such as large side effects, and achieve the effects of reducing the degree of occurrence, having no adverse reactions and reducing pain.

Inactive Publication Date: 2014-02-12
孙伟红 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucocorticoids can significantly reduce acute radiation injury, but long-term use has serious side effects

Method used

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  • Traditional Chinese medicine preparation for preventing and treating radioactive mucositis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1 Traditional Chinese Medicine Oral Liquid 1

[0069] Take 80g of Astragalus, 35g of Radix Paeoniae Alba, 40g of Fritillaria japonicus, 45g of Polygonum cuspidatum, 35g of saponins, 45g of sealwort, 35g of Citrus aurantium, 25g of mint, 40g of Acanthopanax, 30g of Shegan, 35g of Polygonatum 35g, 25g of five-color plum, 35g of mulberry , 25g of fragrant tea vegetables and 35g of white chrysanthemum were mixed to obtain a mixture, soaked in 560g of water for 1 hour, steam distilled for 2 hours, and the volatile oil was collected and stored in another container; Boil for 2 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10 at 55°C, let it cool, add ethanol to make the alcohol content reach 45%, let stand for 24 hours, filter, and recover ethanol; concentrate to 55 The relative density at ℃ is 1.35, and the first extract is obtained by mixing Radix Radix 45g, Licorice 30g, Honeysuckle 65g, Scrophulariaceae 30g, Angelica 4...

Embodiment 2

[0070] Embodiment 2 Chinese medicine oral liquid 2

[0071] Take 78g of Astragalus, 33g of Radix Paeoniae Alba, 38g of Fritillaria japonicus, 43g of Polygonum cuspidatum, 33g of saponins, 43g of Polygonatum, 33g of Citrus aurantium, 23g of Mint, 38g of Acanthopanax, 28g of Shegan, 33g of Polygonatum odoratum, 23g of five-colored plum, and 33g of Sangjisi , 23g of fragrant tea vegetables and 33g of white chrysanthemum were mixed to obtain the mixture, soaked in 560g of water for 1 hour, steamed for 2 hours, and the volatile oil was collected and stored in another container; Boil for 2 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10 at 55°C, let it cool, add ethanol to make the alcohol content reach 45%, let stand for 24 hours, filter, and recover ethanol; concentrate to 55 The relative density at ℃ is 1.35, and the first extract is obtained. Radix Radix 43g, Licorice 28g, Honeysuckle 63g, Scrophulariaceae 28g, Angelica 38g, Anemarrhe...

Embodiment 3

[0072] Embodiment 3 Chinese medicine oral liquid 3

[0073] Take 82g of Astragalus, 37g of Radix Paeoniae Alba, 42g of Fritillaria japonicus, 47g of Polygonum cuspidatum, 37g of saponins, 47g of sealwort, 37g of Citrus aurantium, 27g of mint, 42g of Acanthopanax, 32g of Shegan, 37g of Polygonatum 37g, 27g of five-color plum, and 37g of mulberry , 27g of fragrant tea vegetables and 37g of white chrysanthemum were mixed to obtain a mixture, soaked in 560g of water for 1 hour, steamed for 2 hours, and the volatile oil was collected and stored in another container; Boil for 2 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10 at 55°C, let it cool, add ethanol to make the alcohol content reach 45%, let stand for 24 hours, filter, and recover ethanol; concentrate to 55 The relative density at ℃ is 1.35, and the first extract is obtained. Radix Radix 47g, Licorice 32g, Honeysuckle 67g, Scrophulariaceae 32g, Angelica 42g, Anemarrhena 37g, Ange...

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Abstract

The invention provides a traditional Chinese medicine preparation for preventing and treating radioactive mucositis. The traditional Chinese medicine preparation is prepared from the following raw medicines of astragali radix, isatis root, liquorice, radix paeoniae alba, thunberg fritillary bulb, honeysuckle, figwort root, angelica sinensis, giant knot weed, rhizome of common anemarrhena, radix angelicae, spina gleditsiae, sealwort, ginseng leaf, myrrh, fruit of immature citron, mint, acanthopanax root, eclipta, radix ophiopogonis, blackberry lily, radix polygonati officinalis, subprostrate sophora, puffball, lantana camara, narrow-leaved alternatnthera, loranthus parasiticus, isodon amethystoides and aster ageratoides. The traditional Chinese medicine preparation for preventing and treating the radioactive mucositis, which is provided by the invention, has the advantages that he curative effect is definite, the degree of generating the radioactive mucositis in a radiation process can be effectively reduced, and the pain of the suffers is reduced; by reducing the occurrence rate of radiotherapy complication, the continuity of the treatment is ensured, the course of treatment is shortened, and the curative effect of the tumor treatment is improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for preventing and treating radiation mucositis. [0002] Background technique [0003] Radiation therapy is an effective treatment for head and neck tumors, but the head and neck include three major salivary gland tissues. Radiation therapy can cause damage to salivary glands, resulting in a decrease in saliva secretion, which can lead to a significant increase in susceptibility to various oral diseases, such as Mucositis, xerostomia, radioactive caries, etc. [0004] Radiation acts on the body, causing water molecules to be excited and ionized, resulting in a large number of free radicals, resulting in the breakage of chemical bonds in biomolecules, destruction of molecular structures, and cell death. The increase of radiation dose will increase the size of the ulcer and aggravate the pain. In severe cases, the t...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P1/02A61P35/00
Inventor 宋海平
Owner 孙伟红
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