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Cream for wound surface and preparation method thereof

A technology for cream and wound surface, which is applied in the field of cream for wound surface and its preparation, which can solve the problems such as inability to remove necrotic tissue, and achieve the effects of promoting healing, good spreadability, and relieving pain

Active Publication Date: 2014-02-05
上海达尔威生物技术研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chemotherapy can treat diseases such as sores and gangrene, it cannot remove dead tissue

Method used

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  • Cream for wound surface and preparation method thereof
  • Cream for wound surface and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a) Weigh 0.2g of carbomer, disperse it in 20ml of distilled water, and swell it completely into a clear and transparent liquid, which is liquid A for later use;

[0023] b) Weigh 7g of coconut oil and 1g of self-emulsifying compound emulsifier AC-4021g, heat and melt on a water bath at 85°C; measure 8ml of distilled water, heat on a water bath at 85°C, wait until the oil phase is completely melted, and the water and oil phases reach the same temperature In the case of , add the water phase into the oil phase in a thin stream, and stir while adding to form the emulsion matrix B;

[0024] c) 0.2 g of lidocaine and 4000 units of α-chymotrypsin were dissolved in the remaining distilled water to form solution C;

[0025] d) Add solution C and liquid A to emulsion matrix B and stir to mix evenly, drop 8 drops of triethanolamine, stir and mix evenly, add 1ml of glycerin, 0.3ml of 6% ethylparaben alcohol solution (75% ethanol) and stir to mix Evenly, that is.

Embodiment 2

[0027] a) Weigh 0.5g of carbomer, disperse it in 30ml of distilled water, completely swell into a clear and transparent liquid, and set aside, it is liquid A;

[0028] b) Weigh 8g of coconut oil and 3g of self-emulsifying compound emulsifier AC-4023g, heat and melt on a 75°C water bath; measure 12ml of distilled water, heat on a 75°C water bath, wait until the oil phase is completely melted, and the water and oil phases reach the same temperature In the case of , add the water phase into the oil phase in a thin stream, and stir while adding to form the emulsion matrix B;

[0029] c) 3 g of lidocaine and 30,000 units of α-chymotrypsin were dissolved in the remaining distilled water to form solution C;

[0030] d) Add solution C and liquid A to emulsion base B and stir to mix evenly, drop 12 drops of triethanolamine, stir and mix evenly, add 5ml of glycerin, 1.0ml of 6% ethylparaben alcohol solution (75% ethanol) and stir to mix Evenly, you can.

Embodiment 3

[0032] Except not adding lidocaine, all the other are identical with embodiment 2.

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PUM

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Abstract

The invention discloses a cream for a wound surface and a preparation method thereof. The cream comprises coconut oil, a self-emulsifying compound emulsifier AC-402, alpha-chymotrypsin, lidocaine, glycerin, carbomer, triethanolamine, an ethanol solution of ethylparaben and distilled water. Compared with the prior art, the cream prepared in the invention has the following advantages: the cream comprises alpha-chymotrypsin and lidocaine, and the cream has appropriate viscosity and good coating and spreading performance, is fine and uniform and can clean wound surfaces, eliminate suppurative exudate and necrotic tissue, promote growth of newborn granulation, accelerate healing, mitigate pains and substantially improve compliance of patients, wherein the elimination rate of necrotic tissue reaches more than 90%.

Description

Technical field: [0001] The invention belongs to cream and a preparation method thereof, in particular to a cream for wounds and a preparation method thereof. Background technique: [0002] Unclean, pus and necrotic tissue often appear on the wound of human body burn. Although chemotherapy can treat diseases such as sores and gangrene, it cannot remove necrotic tissue. Contents of the invention [0003] The 1st technical problem to be solved by the present invention is to provide a kind of emulsifiable paste that can remove necrotic tissue for wound surface. [0004] The 2nd technical problem to be solved by the present invention is the preparation method of above-mentioned cream. [0005] The technical problem that the present invention solves is: a kind of emulsifiable cream that is used for wound surface, contains following material in 51g emulsifiable paste: [0006] [0007] The emulsifier is self-emulsifying composite emulsifier AC-402. [0008] Each drop is e...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/06A61P17/02A61P29/00A61K31/167
Inventor 孙淑萍徐文科李胜利王青洋
Owner 上海达尔威生物技术研发有限公司
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