Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Florfenicol/colistin sulfate soluble powder and preparation method thereof

A technology of colistin sulfate and florfenicol, which is applied in powder delivery, antibacterial drugs, pharmaceutical formulations, etc., can solve the problems of synergistic antibacterial effect, unable to meet the scale of breeding, inconvenient use, etc., to achieve good synergistic antibacterial Function, method is simple, and the effect of improving production efficiency

Active Publication Date: 2014-02-05
HENAN SOAR VETERINARY PHARMA
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not only is it inconvenient to use, but also the two drugs enter the body successively, which affects the synergistic antibacterial effect of the two, which cannot meet the needs of the existing breeding scale

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Florfenicol colistin sulfate soluble powder is composed of the following substances by weight percentage: Florfenicol 5%, colistin sulfate 2%, borax 2%, citric acid 30%, potassium bicarbonate 2%, poly Vinylpyrrolidone (k30) 7.5%, poloxamer 188 5%, and the balance is anhydrous glucose.

[0017] The preparation method of florfenicol colistin sulfate soluble powder comprises the following steps:

[0018] (1) Take absolute ethanol twice the mass of polyvinylpyrrolidone (k30), add absolute ethanol into polyvinylpyrrolidone (k30) under stirring, after the polyvinylpyrrolidone (k30) is completely dissolved, at room temperature, separate Add florfenicol, citric acid, borax, potassium bicarbonate and poloxamer 188, stir and mix evenly to obtain soft wood;

[0019] (2) Use absolute ethanol recovery equipment to recover the absolute ethanol in the soft material under reduced pressure to obtain a solid, then dry it at 80°C for 15 minutes, then crush it and pass it through a 60-mes...

Embodiment 2

[0022] Florfenicol colistin sulfate soluble powder is composed of the following substances by weight percentage: Florfenicol 20%, colistin sulfate 20%, borax 0.5%, citric acid 5%, potassium bicarbonate 0.1%, poly Vinylpyrrolidone (k30) 30%, poloxamer 188 1%, and the balance is anhydrous glucose.

[0023] The preparation method of florfenicol colistin sulfate soluble powder comprises the following steps:

[0024] (1) Take absolute ethanol that is 1.8 times the mass of polyvinylpyrrolidone (k30), and add absolute ethanol to polyvinylpyrrolidone (k30) under stirring. After the polyvinylpyrrolidone (k30) is completely dissolved, at room temperature, separate Add florfenicol, citric acid, borax, potassium bicarbonate and poloxamer 188, stir and mix evenly to obtain soft wood;

[0025] (2) Use absolute ethanol recovery equipment to recover the absolute ethanol in the soft material under reduced pressure to obtain a solid, then dry it at 105°C for 30 minutes, then crush it and pass ...

Embodiment 3

[0028] Florfenicol colistin sulfate soluble powder is composed of the following substances by weight percentage: Florfenicol 10%, colistin sulfate 10%, borax 1%, citric acid 15%, potassium bicarbonate 1%, poly Vinylpyrrolidone (k30) 20%, poloxamer 188 3%, and the balance is anhydrous glucose.

[0029] The preparation method of florfenicol colistin sulfate soluble powder comprises the following steps:

[0030] (1) Take absolute ethanol that is 3.6 times the mass of polyvinylpyrrolidone (k30), and add absolute ethanol to polyvinylpyrrolidone (k30) under stirring. After the polyvinylpyrrolidone (k30) is completely dissolved, at room temperature, separate Add florfenicol, citric acid, borax, potassium bicarbonate and poloxamer 188, stir and mix evenly to obtain soft wood;

[0031] (2) Use absolute ethanol recovery equipment to recover the absolute ethanol in the soft material under reduced pressure to obtain a solid, then dry it at 90°C for 20 minutes, then crush it and pass it t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a florfenicol / colistin sulfate soluble powder which is composed of the following components in percentage by weight: 5-20% of florfenicol, 2-20% of colistin sulfate, 0.5-2% of borax, 5-30% of citric acid, 0.1-2% of potassium bicarbonate, 7.5-30% of polyvinylpyrrolidone, 1-5% of poloxamer 188 and the balance of anhydrous glucose. The invention also discloses a preparation method of the soluble powder, which comprises the following steps: dissolving the polyvinylpyrrolidone in anhydrous ethanol, adding the florfenicol, citric acid, borax, potassium bicarbonate and poloxamer 188, evenly mixing, recovering the ethanol, drying, pulverizing, adding the colistin sulfate and anhydrous glucose, and evenly mixing. The soluble powder ensures that the two reagents simultaneously enter the organism and better display the synergic antibacterial action; the method is simple and convenient to operate, and enhances the production efficiency; and the anhydrous ethanol is recovered, so the method protects the environment and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a florfenicol colistin sulfate soluble powder and a preparation method thereof. Background technique [0002] The pharmacological mechanism of florfenicol and colistin sulfate has a synergistic effect, so clinical veterinarians often use the two in combination to enhance the antibacterial effect, expand the antibacterial spectrum, improve the cure rate and reduce the frequency of medication. However, due to the insoluble nature of florfenicol itself, in actual use, colistin sulfate is used to give poultry drinking water; at the same time, florfenicol is used to mix poultry. Not only is it inconvenient to use, but the two medicines enter the body successively, so that the synergistic antibacterial effect of the two medicines is also affected, which cannot meet the needs of the existing breeding scale. Contents of the invention [0003] The object...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/12A61K9/14A61K47/34A61P31/04A61K31/165
Inventor 李凌峰
Owner HENAN SOAR VETERINARY PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com