Compound artemisinin multiphase lipidosome injection as well as preparation method thereof

Abstract

The invention belongs to the field of veterinary drugs, and specifically relates to a compound artemisinin multiphase lipidosome injection as well as a preparation method thereof. The injection comprises a medicinal component and an auxiliary material of the injection, wherein the medicinal component is prepared from artemisinin and diminazene aceturate, and the auxiliary material of the injection consists of lecithin, cholesterol, tween-80, a phosphate buffer and absolute ethyl alcohol. The injection comprises the following components in parts by weight: 1-30 parts of lecithin, 0.5-10 parts of cholesterol, 0.1-5 parts of tween-80, 0.5-5 parts of artemisinin, 0.5-5 parts of diminazene aceturate, 1-15 parts of absolute ethyl alcohol and 5-90 parts of the phosphate buffer. The compound artemisinin multiphase lipidosome injection prepared by the preparation method disclosed by the invention is remarkable in curative effect in treating eperythrozoonosis of livestock and poultry in clinical treatment of veterinarians, and is high in safety. Several methods are organically combined, i.e., an ethanol injection-ultrasonic treatment-homogenization method is adopted. The compound artemisinin multiphase lipidosome injection prepared by the method is high in encapsulation efficiency, good in stability, strong in operability and applicable to industrialized production on a large scale.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and specifically relates to a compound artemisinin multiphase liposome injection with high encapsulation rate, good stability, high safety and remarkable curative effect and a preparation method thereof. Background technique [0002] Artemisinin is a compound that was first isolated from Artemisia annua by Chinese scientists in the early 1970s. It is currently recognized as the most effective drug for the treatment of cerebral malaria and chloroquine-resistant falciparum malaria in the world. It has been approved by the World Health Organization (WHO) recommended drug of choice for the treatment of malaria. [0003] Pharmacological studies have confirmed that in addition to antimalarial effects, artemisinin also has anti-pregnancy, anti-fibrosis, anti-schistosome, anti-toxoplasma, anti-arrhythmia and tumor cytotoxic effects. In veterinary clinics, artemisinin has a strong effect on Eperythrozo...

AI Technical Summary

Problems solved by technology

[0006] Reverse-phase evaporation, freeze-drying, etc. require high equipment and expensive equipment

[0007] In short, the above methods are suitable for laboratory preparation, but there are still some difficulties in applying them in large-scale production.

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