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A kind of wettable sulfamethoxine powder and preparation method thereof

A technology of trimethoprim powder and trimethoprim, which is applied in the field of veterinary drug preparation, can solve the problems of animal refueling stress, failure to achieve therapeutic effect, low drug intake and no curative effect, etc.

Inactive Publication Date: 2016-03-30
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As a broad-spectrum antimicrobial drug with definite curative effect, sulfa-methoxine has been widely used in animal husbandry production in single or compound form. Currently, sulfa-methoxine tablets, compound sulfa-methoxine tablets, and compound sulfa-methoxine tablets are available. Although there are many types of dosage forms such as p-methoxine powder, compound sulfa-methoxine sodium injection, and sulfa-methoxine ditrimethoprim premix, there are still some limitations in application
For example, it is inconvenient to administer medicine when using tablets, and it is not suitable for a large number of group animals; when powders and premixes are used, they need to be administered through feed, and feed administration requires that the drug and feed be mixed evenly, but the actual operation is relatively uniform. Difficult, it is easy to cause animal poisoning due to excessive drug intake or too little drug intake without curative effect; and feed administration can easily change the flavor of the feed, causing animal refueling stress, resulting in a decrease in animal feed intake and failing to reach Therapeutic effect; the therapeutic effect of the injection formulation is good, but time-consuming and laborious, it is not suitable for large-scale farming

Method used

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  • A kind of wettable sulfamethoxine powder and preparation method thereof
  • A kind of wettable sulfamethoxine powder and preparation method thereof
  • A kind of wettable sulfamethoxine powder and preparation method thereof

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preparation example Construction

[0109] The present invention also provides a preparation method of wettable sulfamethoxine powder, comprising the following steps:

[0110] a) Weigh the following raw materials in parts by weight respectively:

[0111]

[0112] b) Mix the raw materials and grind them into fine powders of 625 mesh to 6250 mesh.

[0113] Preferably, the raw materials in the preparation method of wettable sulfamethoxine powder also include one or a mixture of flavoring agent or carrier.

[0114] In some embodiments of the present invention, the preparation method of wettable sulfamethoxine powder comprises the following steps:

[0115] a) Weigh the following raw materials in parts by weight respectively:

[0116]

[0117]

[0118] b) Mix the raw materials and grind them into fine powders of 625 mesh to 6250 mesh.

[0119] Preferably, the raw materials in the preparation method of wettable sulfamethoxine powder also include one or a mixture of flavoring agent or carrier.

[0120] In oth...

Embodiment 1

[0150] The formula screening of embodiment 1 wettable sulfa-methoxine powder

[0151] The screening formula is shown in formula 1 to formula 7 in Table 1:

[0152] The screening formula of table 1 wettable sulfa-methoxine powder of the present invention

[0153]

[0154]

[0155] Weigh the raw materials in each weight percentage of formula 1 to formula 7 in Table 1, mix them uniformly, grind them to 625 mesh ultrafine powder, pack them, and obtain the wettable sulfonamide paramethanone prepared from formula 1 to formula 7. Oxypyrimidine powder.

[0156] The wettable sulfa-methoxine powders prepared from formulas 1 to 7 were evaluated for dispersion quality, sedimentation volume ratio quality evaluation and palatability quality evaluation.

[0157] Dispersion quality evaluation: Take 1g of wettable sulfa-methoxine powder prepared according to formula 1 to formula 7 in Table 1, put them into 1000mL drinking water respectively, observe or stir and observe the dispersion, ...

Embodiment 2

[0173] The preparation of embodiment 2 wettable sulfa-methoxine powder

[0174] formula:

[0175]

[0176] The above-mentioned raw materials are weighed, mixed evenly, crushed to a 625-mesh ultrafine powder, and packaged to obtain the wettable sulfamethoxine powder of the present invention.

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Abstract

The invention relates to the technical field of veterinary medicine preparation, and particularly relates to wettable sulfamethoxydiazine powder and a preparation method thereof. The wettable sulfamethoxydiazine powder provided by the invention is added with potassium citrate, a suspending agent and a wetting agent on the basis of effective components of the original medicine; by reasonable medicine proportioning, the invention provides the wettable sulfamethoxydiazine powder which is easy to disperse evenly in water and convenient to take with water. Compared with commercially available compound sulfamethoxydiazine powder, the wettable sulfamethoxydiazine powder is good in therapeutic effect, convenient to use and small in toxic and side effects. The invention also provides the preparation method of the wettable sulfamethoxydiazine powder, and the preparation method is simple in technology, low in production cost and suitable to industrialized production.

Description

technical field [0001] The invention relates to the field of preparation of veterinary drugs, in particular to a wettable sulfamethoxine powder and a preparation method thereof. Background technique [0002] Sulfamethoxydiazine (Sulfametoxydiazine, SMD), also known as Bayrena, Durenat, Kinecid, Kirocid, Sulfameter, Sulfametin, Sulphamethoxydiazine, Sulla, long-acting sulfonamide D, methosulfonamide, anti-inflammatory sulfonate, the chemical name is 2-[p-aminobenzene Sulfonamido]-5-methoxypyrimidine, the molecular formula is C 11 h 12 N 4 o 3 S, is an odorless, slightly bitter taste of white or yellowish crystal or powder. Sulfa-p-methoxine is slightly soluble in ethanol, almost insoluble in water or ether, easily soluble in sodium hydroxide solution, slightly soluble in dilute hydrochloric acid, and has a melting point of 210°C to 214°C. [0003] Sulfamethoxine is structurally similar to p-aminobenzoic acid (PABA), which can compete with PABA to act on the dihydrofolate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K9/14A61K47/38A61K47/04A61K47/10A61K33/12A61P15/02A61P29/00A61P31/04A61P33/02A61K31/505
Inventor 丁晓刚周亮言房春林李犹平徐莎
Owner CHENGDU QIANKUN VETERINARY PHARMA
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