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Wettability solid dispersing powder of florfenicol composition and preparation method thereof

A florfenicol and solid dispersion technology, which is applied in the directions of non-active components of polymer compounds, organic active components, medical preparations containing active components, etc., can solve the problems of inconvenient use of florfenicol powder and premix, Uneven administration and application, complex dissolution process, etc., to avoid the stress reaction of livestock refueling, uniform administration, and easy to use

Active Publication Date: 2014-01-29
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Each of the existing preparations can meet a part of the production needs of livestock breeding, but each preparation has certain limitations or shortcomings. For example, the bioavailability of florfenicol injection is relatively low, and it is only suitable for small-scale Farmers; florfenicol powder and premix are inconvenient to use; florfenicol solution has peculiar smell due to the use of organic solvents, and the cost is relatively increased; florfenicol soluble powder needs a special co-solvent, and the dissolution process Complicated, slow dissolution at low temperature, etc., resulting in complicated operation of these florfenicol preparations during administration, and easy to cause uneven administration and limit its promotion and application

Method used

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  • Wettability solid dispersing powder of florfenicol composition and preparation method thereof
  • Wettability solid dispersing powder of florfenicol composition and preparation method thereof
  • Wettability solid dispersing powder of florfenicol composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Screening of florfenicol composition wettable solid dispersion powder formula

[0048] The type, dosage, and combination of excipients are important factors for preparations, and they are directly related to the availability of pharmaceutical preparations and the quality of the obtained preparations. For the "wettable solid dispersible powder of florfenicol composition" of the present invention, the most important inspection indicators are the degree of dispersion and the sedimentation rate. In order to prepare a wettable powder with uniform dispersion and slow sedimentation speed, the present invention screens its formulations.

[0049] formula:

[0050] The experiment designed 6 different florfenicol composition wettable solid dispersible powder formulas, and the composition of each formula is shown in Table 1.

[0051] Table 1 The formula of the wettable solid dispersion powder of the florfenicol composition of the present invention

[0052]

[0053] Preparation:

...

Embodiment 2

[0062] Example 2 Preparation of wettable solid dispersion powder of florfenicol composition

[0063] Take 20kg of Florfenicol, 21kg of hydroxypropyl-β-cyclodextrin, Tween-602.6kg, 1000mg of Vitamin E, 2000mg of butylated hydroxyanisole, mix well, add 20L of absolute ethanol, stir until it is dissolved, then add 45.5 kg of anhydrous glucose and 10.9 kg of sodium dihydrogen phosphate, mixed uniformly, ventilated and dried at 50°C for 4 hours, then smashed with 2000 meshes to obtain.

Embodiment 3

[0064] Example 3 Preparation of florfenicol composition wettable solid dispersion powder

[0065] Take 2kg of florfenicol, 30kg of hydroxypropyl-β-cyclodextrin, Tween-6010kg and 400mg of butylated hydroxyanisole, mix well, add 2L of absolute ethanol, stir until it is dissolved, then add 57.4 of anhydrous glucose kg, 18 kg of sodium dihydrogen phosphate, mix well, ventilate and dry at 40°C for 6 hours, then crush with 80 mesh to obtain.

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Abstract

The invention belongs to the technical field of pharmaceutic preparation, and discloses a wettability solid dispersing powder of florfenicol composition and a preparation method thereof. The wettability solid dispersing powder of florfenicol composition is prepared from the following raw materials in parts by weight: 2-21 parts of florfenicol, 21-39 parts of hydroxypropyl-beta-cyclodextrin, 2.6-10 parts of tween-60, 27.5-57.4 parts of anhydrous dextrose, 10-18 parts of sodium dihydrogen phosphate and 0.0004-0.0042 part of pharmaceutically accepted antioxidant. The wettability solid dispersing powder of florfenicol composition remarkably improves the dispersity of florfenicol in water, can be prepared into injection and dry suspension, and is convenient to use, even in administration, low in side effect and more beneficial to popularization and application of florfenicol in animal husbandry and aquaculture industry. The preparation method of the wettability solid dispersing powder of florfenicol composition is simple in process, low in production cost and suitable for industrial production.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a wettable solid dispersion powder of a florfenicol composition and a preparation method thereof. Background technique [0002] Florfenicol, also known as fluprofen, is a monofluoro derivative of thiamphenicol, so it is also commonly known as florfenicol and its chemical name is D(+)-threo-l-p-methylsulfonyl Phenyl-2-dichloroacetamido-3-fluoropropanol, molecular formula is C 12 H 14 NO 4 C 12 SF, the molecular weight is 358.22, which has the structure shown in formula I, [0003] [0004] Florfenicol is a broad-spectrum veterinary antibacterial drug, a new type of chloramphenicol antibacterial, which has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, safety and efficiency, etc., and it is resistant to livestock and poultry bacteria caused by sensitive bacteria. The disease treatment effect is remarkabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/10A61K9/00A61K31/165A61K47/40A61P31/04
Inventor 丁晓刚房春林李犹平李超
Owner CHENGDU QIANKUN VETERINARY PHARMA
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