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Preparation method and application of thrombus removing and collaterals dredging tablets

A technology of Xiaoshuantongluo and Salvia miltiorrhiza is applied in the field of preparation of Xiaoshuantongluo tablets, which can solve the problems of large dosage, many impurities, inconvenient taking of patients and the like, and achieve the effect of reducing dosage.

Active Publication Date: 2014-01-08
JILIN ZHENGHE PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Xiaoshuan Tongluo Tablets. However, the method of powdering and boiling in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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  • Preparation method and application of thrombus removing and collaterals dredging tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 120g of Rhizoma Chuanxiong, 90g of Salvia miltiorrhiza, 180g of Radix Astragali, 60g of Alisma, 60g of Panax notoginseng, 30g of Sophora japonica, 60g of cassia twig, 60g of turmeric, 30g of woody fragrance, 2.4g of borneol, and 60g of hawthorn into the CO2 supercritical extractor, ethanol As an entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 150min to obtain a supercritical extract, adding starch and 70% ethanol Make granules, dry, and tablet to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 120g of Chuanxiong, 90g of Salvia, 180g of Astragalus, 60g of Alisma, 60g of Sanqi, 30g of Sophora japonica, 60g of Guizhi, 60g of Curcuma, 30g of Muxiang, 2.4g of Borneolum, and 60g of Hawthorn into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, and the extraction time is 180min to obtain a supercritical extract, which is added with starch and 70% ethanol to make granules, dried, and pressed into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 120g of Chuanxiong, 90g of Salvia, 180g of Astragalus, 60g of Alisma, 60g of Sanqi, 30g of Sophora japonica, 60g of Guizhi, 60g of Curcuma, 30g of Muxiang, 2.4g of Borneolum, and 60g of Hawthorn into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method of thrombus removing and collaterals dredging tablets. The thrombus removing and collaterals dredging tablets are prepared by performing supercritical extraction on 120 g of ligusticum wallichii, 90 g of salviae miltiorrhizae, 180 g of astragalus membranaceus, 60 g of alisma orientalis, 60 g of pseudo-ginseng, 30 g of flos sophorae, 60 g of cassia twig, 60 g of curcuma aromatica, 30 g of elecampane, 2.4 g of borneol and 60 g of hawthorn serving as raw materials, so that the content of each raw material is greatly improved, and the dose is reduced. The invention also provides application of the thrombus removing and collaterals dredging tablets in preparation of a medicament for inhibiting the cell proliferation of human acute promyelocytic leukemia cell NB4.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Xiaoshuan Tongluo Tablet. Background technique [0002] Xiaoshuan Tongluo Tablet is recorded in Pharmacopoeia, the prescription is Chuanxiong 120g, Salvia miltiorrhiza 90g, Astragalus 180g, Alisma 60g, Panax notoginseng 60g, Sophora japonica 30g, Guizhi 60g, Curcuma 60g, Muxiang 30g, Borneol 2.4g, Hawthorn 60g , the above eleven flavors, grind borneol into fine powder, grind Panax notoginseng into fine powder; decoct the remaining nine flavors such as Chuanxiong and other nine flavors with water, combine the decoction, filter, and concentrate the filtrate under reduced pressure to form a clear paste with a relative density of 1.35-1.40, add The fine powder of notoginseng is dried, made into granules, dried, added with fine powder of borneol, mixed evenly, pressed into tablets, coated with sugar or film, and...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/20A61P35/02A61K31/045
Inventor 不公告发明人
Owner JILIN ZHENGHE PHARMA GRP
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