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Fully degradable high molecular material cardiovascular stent

A polymer material and cardiovascular technology, applied to the composition and preparation process of polymer materials for special performance stents, the field of polymer cardiovascular stents

Active Publication Date: 2014-01-01
黄晚兰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Because the component of the existing BVS stent is PLLA, its degradation time in vivo is about 3 to 4 years

Method used

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  • Fully degradable high molecular material cardiovascular stent
  • Fully degradable high molecular material cardiovascular stent
  • Fully degradable high molecular material cardiovascular stent

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Experimental program
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Effect test

Embodiment Construction

[0036] Preparation of fully degradable polymer material cardiovascular stent

[0037] Step 1: Blending PLLA and PLGA with a composition ratio of 70 / 30. The intrinsic viscosity of PLLA is 4. The composition of PLGA is PL / GA=90 / 10.

[0038] Step 2: Extrude the original pipe from the polymer material, such as figure 1 shown. The polymer raw pipe is formed by an extrusion process. The extrusion process is carried out in a small twin-screw extruder. The length and diameter ratio of the extruder is 24:1, the compression ratio is 3.3:1, the screw selection speed is 10rpm, and the temperature It is set at 210°C, the pressure is from 3000psi, a die is used at the extrusion port, the diameter size is 3mm, the temperature of the extrusion head is 230°C, and the pressure is 600psi. The polymer material is pre-dried at 60°C, and at a certain temperature, the polymer material is melted, and a certain pressure is applied to extrude the molten polymer material, and then the original pipe ...

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Abstract

All coronary stents used on the current market are made of a metallic material, cannot be degraded and are remained in the coronaries of human bodies permanently once implanted. The new stent technology is developed towards the degradable high molecular material. The stent is made by melt-mixing PLLA (Poly L-Lactic Acid) and PLGA (Poly(Lactic-co-Glycolic Acid)) high molecules, so that sufficient mechanical support can be provided and the in-vivo degradation time is also much less than that of the pure PLLA stent. According to the stent, an original tube is injection molded, is annularly plasticized into a precursor tube and is laser-engraved into the stent; the stent has specific internal diameter and external diameter and is annularly coupled and clamped on a balloon when being implanted into the human body. The stent has sufficient strength and plasticity and good degradability and biocompatibility. The optimal ratio for melt mixing of PLLA and PLGA high molecules is discovered. According to the brand new technology, the annular distribution of a polymer molecular chain is effectively controlled and induced, and the damage to the polymer molecular chain is reduced as much as possible. The integral performance of the stent is affected through preferable structural design of the tube.

Description

technical field [0001] The invention belongs to the field of three types of medical devices. The invention relates to an expandable implantable prosthesis, and more specifically relates to a polymer cardiovascular stent, which is expanded with a balloon after implanted in a blood vessel. The stent is made of fully degradable polymer material. The invention also relates to the polymer material composition and preparation process of the special performance bracket. Background technique [0002] An "implant-like prosthesis" corresponds to a device that can be implanted inside the body, placed within an anatomical cavity, more specifically, a "cavity" refers to a hollow tubular organ such as a blood vessel. A stent is an example of a prosthesis. Stents are generally cylindrical devices whose function is to enlarge vessel segments or other anatomical lumens, such as the urethra and bile ducts. Stents are commonly used in the treatment of narrowing of blood vessels due to athe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61F2/915
Inventor 黄晚兰崔菡
Owner 黄晚兰
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