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Preparation method of avermectin-griseofulvin composite nano-emulsion pesticide

A technology of griseofulvin and abamectin, which is applied in the directions of insecticides, botanical equipment and methods, acaricides, etc., can solve the problems of difficult absorption of pests, short killing duration, etc., and achieves strong efficacy. , Long lasting effect, stable drug effect

Active Publication Date: 2013-12-25
江苏物网慧农科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some antibiotic drugs are poorly soluble drugs, which are difficult to absorb when entering the pest body, and the killing duration is short, which requires the application of modern pharmacy principles to design new dosage forms

Method used

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  • Preparation method of avermectin-griseofulvin composite nano-emulsion pesticide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prescription: 10 parts of abamectin, 10 parts of griseofulvin, 150 parts of ethyl oleate, 30 parts of albumin, and 12 parts of n-butanol.

[0020] Above-mentioned abamectin and griseofulvin composite nanoemulsion insecticide, its preparation method comprises the steps:

[0021] (1) Add avermectin, griseofulvin and albumin to ethyl oleate to obtain an oil phase solution;

[0022] (2) Under stirring conditions, add the above oil phase solution into water to obtain an oil-water mixture;

[0023] (3) Add n-butanol into water, and slowly add it dropwise into the above oil-water mixture at a temperature of 35°C until the solution is transparent to obtain an oil-in-water nanoemulsion.

[0024] The abamectin and griseofulvin composite nanoemulsion insecticide prepared in this example has the characteristics of stable drug, strong drug effect and long duration of action, and has gastric poisoning and contact killing effects on mites and insects.

Embodiment 2

[0026] Prescription: 10 parts of abamectin, 5 parts of griseofulvin, 100 parts of soybean oil, 10 parts of soybean lecithin, 10 parts of lecithin, and 10 parts of ethylene glycol.

[0027] Above-mentioned abamectin and griseofulvin composite nanoemulsion insecticide, its preparation method comprises the steps:

[0028] (1) Add abamectin, griseofulvin, soybean lecithin and lecithin to soybean oil to obtain an oil phase solution;

[0029] (2) Under stirring conditions, add the above oil phase solution into water to obtain an oil-water mixture;

[0030] (3) Add ethylene glycol into water, and slowly add it dropwise into the above oil-water mixture at a temperature of 30°C until the solution is transparent to obtain an oil-in-water nanoemulsion.

[0031] The abamectin and griseofulvin composite nanoemulsion insecticide prepared in this example has the characteristics of stable drug, strong drug effect and long duration of action, and has gastric poisoning and contact killing effe...

Embodiment 3

[0033] Prescription: 10 parts of abamectin, 15 parts of griseofulvin, 200 parts of liquid paraffin, 30 parts of albumin, 10 parts of lecithin, 15 parts of ethanol and n-butanol.

[0034] Above-mentioned abamectin and griseofulvin composite nanoemulsion insecticide, its preparation method comprises the steps:

[0035] (1) Add abamectin, griseofulvin, albumin and lecithin to liquid paraffin to obtain an oil phase solution;

[0036] (2) Under stirring conditions, add the above oil phase solution into water to obtain an oil-water mixture;

[0037] (3) Add ethanol and n-butanol into water, slowly drop them into the above oil-water mixture at a temperature of 40°C until the solution is transparent, and then the oil-in-water nanoemulsion is obtained.

[0038] The abamectin and griseofulvin composite nanoemulsion insecticide prepared in this example has the characteristics of stable drug, strong drug effect and long duration of action, and has gastric poisoning and contact killing ef...

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Abstract

The invention discloses a preparation method of an avermectin-griseofulvin composite nano-emulsion pesticide. The avermectin-griseofulvin composite nano-emulsion pesticide is prepared from 10 parts of avermectin, 5-15 parts of griseofulvin, 100-200 parts of an oil phase, 20-40 parts of an emulsifier and 10-15 parts of a co-emulsifier. Compared with the prior art, the avermectin-griseofulvin composite nano-emulsion pesticide has the characteristics of good medicinal stability, strong medicinal effects and long action period. The avermectin-griseofulvin composite nano-emulsion pesticide has stomach poisoning and contact toxicity effects on mites and insects, is mainly used for killing internal and external parasites of livestock and poultry and injurious insects of crops, and can prevent and control a plurality of injurious insects such as parasitic red insects, dipteran, coleopteran, lepidopteran and pest mites on a plurality of crops such as orange, woods, cotton, vegetables, tobacco and paddy rice.

Description

technical field [0001] The invention relates to a preparation method of biological pesticides, in particular to a preparation method of abamectin and griseofulvin composite nanoemulsion insecticide, which is applied in the field of agriculture. Background technique [0002] Biopesticides refer to living organisms and their metabolites and genetically modified products used to prevent and control harmful organisms such as diseases, insects, and grasses, and can be made into commercial biological source preparations, including bacteria, viruses, fungi, nematodes, plants, natural enemies of insects, Agricultural antibiotics, plant growth regulators and transgenic plants resistant to diseases, insect pests and weeds, etc. Biological pesticides have been used in agricultural production for half a century, but the development has been relatively slow due to various reasons. In recent years, people pay more and more attention to the sustainable development of agricultural producti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/04A01P7/04A01P7/02A01N43/12
Inventor 卞佳林
Owner 江苏物网慧农科技集团有限公司
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