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Application of Incarviatone A in anti-human fungus drug

A technology against human fungi and drugs, applied in the direction of antifungal agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc. Active effect

Inactive Publication Date: 2013-12-18
NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Incarviatone A in anti-human fungus drug
  • Application of Incarviatone A in anti-human fungus drug
  • Application of Incarviatone A in anti-human fungus drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Incarviatone A tablet involved in the present invention:

[0013] Take 20 grams of compound Incarviatone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Incarviatone A capsules involved in the present invention:

[0015] Get 20 grams of compound Incarviatone A, add conventional excipients for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Incarviatone A anti-fungal activity in humans

[0018] Anti-human fungus activity experiment is the method of concentration dilution, each determination is repeated three times, the test pathogens include Trichophyton rubrum, Microsporum lanoides and Trichophyton cleavus, and the concentration of bacteria solution is 105 / mL. The initial concentration of Incarviatone A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the equal volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungal culture temperature 28°C respectively, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Incarviatone A against human fungi are shown in Table 1.

[0019] Table 1 Incarviatone A anti-human fungal MIC value (μ...

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PUM

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Abstract

The invention relates to application of Incarviatone A in preparation of an anti-human fungus drug and belongs to the field of medicine. The Incarviatone A has good inhabiting effect on trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, so that the Incarviatone A can serve as an anti-human fungus compound and is hopefully applied in preparation of related drugs. The application of the Incarviatone A in the preparation of the anti-human fungus drug is disclosed for the first time. Due to the fact that the skeleton type is a novel skeleton type and the high human fungus inhibitory activity Incarviatone A is previously unimagined, the possibility that other compounds give any revelation does not exist, and the Incarviatone A has outstanding substantive characteristics and meanwhile has a remarkable improvement in prevention and treatment of human fungus obviously.

Description

technical field [0001] The present invention relates to the application of Incarviatone A, in particular to the application of Incarviatone A in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Incarviatone A ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P31/10
Inventor 江春平黄蓉
Owner NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH
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