Application of Incarviatone A in drug for treating hemorrhagic fever with renal syndrome

A technology for renal syndrome and hemorrhagic fever, which can be applied to drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve problems such as uncertain effects, and achieve strong viral inhibitory activity and outstanding essence in hemorrhagic fever with renal syndrome. effects of sexuality

Inactive Publication Date: 2013-12-18
李浩福
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral treatments such as ribavirin and interferon are often used clinically, but the effect is not yet certain

Method used

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  • Application of Incarviatone A in drug for treating hemorrhagic fever with renal syndrome
  • Application of Incarviatone A in drug for treating hemorrhagic fever with renal syndrome
  • Application of Incarviatone A in drug for treating hemorrhagic fever with renal syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Incarviatone A tablet involved in the present invention:

[0013] Take 20 grams of compound Incarviatone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Incarviatone A capsules involved in the present invention:

[0015] Get 20 grams of compound Incarviatone A, add conventional excipients for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] In order to better understand the essence of the present invention, the experimental results of Incarviatone A will be described below to illustrate its application in the field of pharmacy.

[0018] The specific experiment is as follows:

[0019] 1. Experimental study of Incarviatone A against hemorrhagic fever with renal syndrome virus

[0020] (1) In vitro inhibition experiment of hemorrhagic fever with renal syndrome virus

[0021] 1 material

[0022] (1) Virus strain: the international standard strain of hemorrhagic fever with renal syndrome virus 76-118, which is preserved by th...

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Abstract

The invention discloses novel application of Incarviatone A in preparation of a drug for treating hemorrhagic fever with renal syndrome. In-vitro and in-vivo inhibition experimental study on the effect of the Incarviatone A to hemorrhagic fever virus with renal syndrome shows that the Incarviatone A has low toxic effect on cells, has the direct killing effect on the hemorrhagic fever virus with renal syndrome, can obviously inhabit viral multiplication, has obvious protecting effect on susliks infected with the virus and enables the disease time to be postponed, the disease course to be prolonged and the death rate to be reduced. Therefore, the Incarviatone A is an effective and safe drug for treating the hemorrhagic fever with renal syndrome.

Description

technical field [0001] The present invention relates to the use of Incarviatone A, in particular to the use of Incarviatone A in the pharmaceutical field. Background technique [0002] There are 13 kinds of human viral hemorrhagic fever in the world. According to whether the disease has kidney damage, it is divided into two categories: with kidney damage and without kidney damage. In my country, it is mainly hemorrhagic fever with renal syndrome (HFRS), also known as epidemic hemorrhagic fever. Hemorrhagic fever (EHF); called Korean hemorrhagic fever (KHF) in North Korea; called hemorrhagic nephritis nephritis (HNN) in the Soviet Union; due to the establishment of specific serological diagnosis and the resolution of etiology, in 1982, the World Health Organization named it as renal syndrome Symptoms of hemorrhagic fever. [0003] The disease is caused by Korean hemorrhagic fever virus (or Hantaan virus), a natural foci disease with rodents as the main source of infection; it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/14A61P13/12
Inventor 江春平黄蓉
Owner 李浩福
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