Compound mangosteen medicament and preparation process thereof

The technology of Shanzhu and medicine is applied in the field of compound Shanzhu medicine and its preparation, which can solve the problems of not hindering the progress of the disease, and achieve the effects of good clinical application prospect, definite curative effect and less dosage.

Active Publication Date: 2013-12-11
WUHAN YIYUANTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral administration of traditional Chinese medicine, massage therapy, topical external use, plaster, liniment, iontophoresis, acupuncture and small needle-knife therapy cannot hinder the progress of the disease, and most of them can only be used as part of comprehensive treatment to partially relieve osteoarthritis Symptoms and delay the progression of the disease, but still have not become a recognized clear and effective treatment

Method used

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  • Compound mangosteen medicament and preparation process thereof
  • Compound mangosteen medicament and preparation process thereof
  • Compound mangosteen medicament and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Weigh 10g of the dried mangosteen peel, reflux extraction with 8 times the weight of 50% ethanol for three times, each time for 2 hours, extract the ethanol at 60°C and pressure of -0.003mpa to recover ethanol under reduced pressure, and make it into a flow immersion ointment;

[0024] (2) Dry the liquid extract by microwave at 40°C, and then pulverize it to obtain extract powder;

[0025] (3) After the extract powder is granulated, it is uniformly mixed with 0.5 g of aspartic acid, and it is made into a hard capsule by a conventional method.

Embodiment 2

[0026] Example 2: Repeat Example 1 according to the same steps as described, but in step (1), the mass of safflower is 60g; the concentration of ethanol is 90%; the extract is at 40°C, and the pressure is -0.009mpa. Ethanol was recovered; in step (2), the liquid extract was dried by microwave at 80°C; in step (3), the extract powder was granulated and mixed evenly with 5 g of aspartic acid to make a paste by conventional methods.

Embodiment 3

[0027] Example 3: Repeat Example 1 according to the same steps as described, but in step (1), the mass of safflower is 30g; the concentration of ethanol is 70%; the extract is at 75°C, and the pressure is -0.006mpa. Ethanol was recovered; in step (2), the fluid extract was dried by microwave at 60°C; in step (3), the extract powder was granulated and mixed evenly with 3 g of aspartic acid, and made into soft capsules by conventional methods.

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Abstract

The invention discloses a compound mangosteen medicament. The medicament is prepared by mixing the following raw materials in a weight ratio: 10g-60g of mangosteen and 0.5g-5g of L-aspartic acid calcium salt. The invention also provides a preparation process of the compound mangosteen medicament and the preparation process comprises the following steps of: (1) weighing mangosteen, refluxing and extracting with ethanol to prepare fluid extract; (2) preparing the fluid extract into extract powder; (3) granulating the extract powder, and uniformly mixing the granules and the L-aspartic acid calcium salt, and preparing a preparation by a conventional method. The medicament provided by the invention can be used for treating osteoarthritis, osteoporosis and osteoarthritis complicated with osteoporosis, is safe and effective, and has the characteristics of exact curative effect, small dosage, safe administration, no toxic or side effect and the like, compared with similar medicaments.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a compound shanzhu medicine and a preparation process thereof. Background technique [0002] Osteoarthritis (OA), also known as degenerative arthritis, is a chronic, progressive, degenerative joint disease that is a common disease in middle-aged and elderly people. Its incidence increases with age. According to statistics, the incidence rate of the population over 50 years old in my country is 5%, and the incidence rate of knee osteoarthritis is 9.56%. The incidence rate of population over 60 years old is 20%. The incidence rate of arthritis is 78.5%. It is conservatively estimated that there are at least 30 million OA patients of varying degrees in my country. OA is one of the important causes of disability, and many patients can only choose joint replacement in the later stage. There are many clinical treatment methods for osteoarthritis, but so far none of them can effective...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P19/02A61P19/10A61K31/198
Inventor 熊义涛喻小军周从辉王红芳
Owner WUHAN YIYUANTANG BIOTECH
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