Separate multimode fusion three-dimensional tomography system and method

Abstract

The invention discloses a separate multimode fusion three-dimensional tomography system and a separate multimode fusion three-dimensional tomography method. The system comprises a data source transmission module, a data acquisition module, a system control and data transmission module and a data processing module, wherein the data source transmission module is used for transmitting X rays and an exciting light source to irradiate a sample respectively; the data acquisition module is used for detecting the dose of the X rays passing through the sample, and receiving fluorescent information excited from the sample; the system control and data transmission module is used for controlling the ordered operation of each module in the system; the data processing module is used for processing the acquired imaging data of the sample, and three-dimensionally reconstructing the structure information of the sample and light source distribution information. The system and the method can be used for realizing the real-time and nondestructive multimode image acquisition of in vivo fluorescence molecular imaging and X-ray tomography, the biological information of an imaging sample can be rapidly obtained, influence between modes is overcome in terms of physical position, and meanwhile, different mode data of the imaging sample can be well fused in terms of physical position.

Description

technical field [0001] The invention belongs to the field of medical molecular imaging, and in particular relates to a separate multi-mode fusion three-dimensional tomographic imaging system and a method thereof. Background technique [0002] Medical molecular imaging technology can noninvasively, continuously, in vivo, and early visualize the expression and activity of specific molecules that affect tumor behavior and tumor response to drug treatment, as well as physiological processes, breaking through the traditional imaging technology that can only display the anatomy caused by lesions. Limitations of Structural Change. [0003] Compared with other small animal in vivo molecular imaging equipment, the optical molecular imaging system has many advantages such as high sensitivity, good specificity, intuitive results, fast measurement, and low cost. These advantages make it develop into an ideal small animal in vivo imaging technology, and gradually become an indispensable...

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Problems solved by technology

[0004] Therefore, in recent years, some challenging issues involving multimodal molecular imaging systems and methods have gradually emerged: whether the same imaging system can be used to perform multiple physiological studies on the same organism at the molecular level, functional metabolism level, and anatomical structure level. Can the imaging and fusion of pathological information make full use of the positioning and quantitative data information provided by multi-modal molecular imaging in the study of the pathogenesis of major diseases such as tumors? Complementary, so as to obtain more comprehensive and complete physiological and pathological information at the level of anatomical structure, functional metabolism and cell molecules; this has also become a new trend in the development of current molecular imaging technology, and it is also a very challenging problem.

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