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Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone by using a dosing algorithm to provide analgesia

A technology for intravenous administration of opioids, applied in the field of pain treatment of patients, capable of solving problems such as differences in the proportion of pain relief

Inactive Publication Date: 2013-11-27
QRXPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, there are wide and clinically important differences in published opioid equivalent analgesic ratios

Method used

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  • Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone by using a dosing algorithm to provide analgesia
  • Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone by using a dosing algorithm to provide analgesia
  • Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone by using a dosing algorithm to provide analgesia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] The patient underwent the operation completed at 12:30PM, so IV PCA morphine started at 1:00PM. Stop the IV PCA administration of morphine at 7:00 AM the next morning and switch the patient to oral It is a combination of morphine sulfate and oxycodone hydrochloride in a weight ratio of about 3:2 in an immediate-release oral administration form. Therefore, a total of 18 hours of IV PCA morphine administration from the beginning to the end of IV PCA morphine administration can be used for the calculation of the algorithm. During the first 4 hours of the total time of IV PCA morphine dosing, the patient received 9 mg of morphine. The patient received a total of 129 mg of morphine during the total time of IV PCA morphine administration. Therefore, the net amount of morphine administered via IV PCA is calculated by subtracting 9 mg (the amount of IV PCA morphine administered during the first 4 hours of IV PCA) from the total amount of 129 mg to give a passing rate of 120 m...

Embodiment 2

[0140] The patient underwent the operation completed at 2:00PM, so IV PCA morphine started at 2:30PM. Stop IV PCA administration of morphine at 7:30 AM the next morning and switch the patient to oral It is a combination of morphine sulfate and oxycodone hydrochloride in an immediate release form in a weight ratio of approximately 3:2. Therefore, a total of 17 hours of IV PCA morphine administration from the start to the end of IV PCA morphine administration can be used for the calculation of the algorithm. During the first 4 hours of the total time of IV PCA morphine dosing, the patient receives 9 mg of morphine IV PCA, and the nurse administers 2 mg of IV morphine through the PCA pump, so that a total of 11 mg of IV morphine during the first 4 hours. The patient receives a total of 60 mg of morphine during the total time of IV PCA morphine administration. Therefore, the net amount of morphine administered via IV PCA is calculated by subtracting the amount of IV PCA morphine...

Embodiment 3

[0142] Take a flexible dose of 3:2 ratio of morphine sulfate to oxycodone hydrochloride orally Open, multi-center, multi-dose experimental research, and (1-2 tablets of 5mg / 325mg oxycodone / acetaminophen) comparison, treatment of acute moderate to severe postoperative pain after unilateral total knee arthroplasty or total hip arthroplasty. One purpose of this study is to evaluate the accuracy of the algorithm that converts IV PCA morphine into an oral morphine equivalent dose administered every 4-6 hours during a 48-hour treatment period. Also evaluate any adverse events, including treatment-related adverse events (TEAE) or serious adverse events (SAE), including possible signs of abuse.

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Abstract

A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release mgrphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents, a one-hour average oral morphine equivalents, or determining a net average hourly inlravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm lo determine the first dose of the immediate release morphine-oxycodone combination.

Description

[0001] Cross references to related applications [0002] This application requires a U.S. Patent Application Serial No. 12 / 881,677 filed on September 14, 2010 and granted on April 12, 2011 as U.S. Patent No. 7,723,453; filed on September 14, 2010 and in September 2011 U.S. Patent Application Serial No. 12 / 881,728, granted on the 6th as U.S. Patent No. 8,012,990; and priority of U.S. Patent Application Serial No. 13 / 185,016 filed on July 18, 2011; all of these are incorporated herein by reference. Technical field [0003] The present invention relates to the treatment of pain in patients. In certain aspects, the present invention relates to a method of converting a patient's pain treatment regimen from intravenous (IV) administration of opioids to oral administration of a combination of morphine and oxycodone in a weight ratio of about 3:2. This method can include the use of a dosing algorithm to determine the appropriate dose of the morphine and oxycodone combination. Background ...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K45/06A61P25/04
CPCA61K31/485A61K45/06A61P25/04A61K2300/00
Inventor P·T·理查森W·C·斯特恩L·J·门勒-高B·D·施瓦茨
Owner QRXPHARMA
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