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Method for establishing dog vagal trunk nerve stimulation-induced AF (atrial fibrillation) experimental model

An experimental model, a technology for establishing methods, applied in artificial respiration, physical therapy, etc., to achieve the effect of increasing the duration, increasing the induction rate and stability

Inactive Publication Date: 2013-11-20
侯月梅
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AI Technical Summary

Problems solved by technology

Some domestic scholars have also explored the production of AF models such as atrial pacing, heart failure (abbreviated as heart failure) and inflammation, but have not yet established a method for making vagus nerve-mediated AF animal models in the vagus nerve trunk, and there are no different levels of vagus nerve effects and AF-induced comparison between rates

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  • Method for establishing dog vagal trunk nerve stimulation-induced AF (atrial fibrillation) experimental model
  • Method for establishing dog vagal trunk nerve stimulation-induced AF (atrial fibrillation) experimental model
  • Method for establishing dog vagal trunk nerve stimulation-induced AF (atrial fibrillation) experimental model

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Embodiment Construction

[0015] Concrete implementation steps of the present invention are as follows

[0016] 1. Animal anesthesia: Anesthetize 10 adult healthy mongrel dogs weighing 18-23 kg: intramuscular injection of ketamine 10 mg / kg bolus, intraperitoneal injection of 5% thiopental sodium 25 mg / kg; establishment of intravenous access, intravenous infusion of anesthesia Pain compound solution (ingredients: 5% glucose injection 250ml, 50% procaine injection 5ml, acetylsuccinylcholine injection 200mg); after blocking spontaneous breathing, endotracheal intubation, ventilator, adjust oxygen flow 4 ~6L / min, tidal volume 10ml / L; self-made needle electrodes were inserted under the skin of animal limbs to record and monitor standard body surface electrocardiograms; endocardial electrocardiograms were measured using a German HELLE Cardio-2000 electrophysiological mapper, frequency The sound range is 30-500Hz; the recording paper speed is 100mm / s; the surface electrocardiogram is 0.1-100Hz;

[0017] 2. E...

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Abstract

The invention discloses a method for establishing a dog vagal nerve trunk stimulation-induced AF (atrial fibrillation) experimental model. The method comprises the following steps: 1, narcotization of an animal; 2, placement of an electrophysiological mapping catheter; 3, electrophysiological examination; and 4, induction and termination of AF. The method for establishing the dog vagal nerve trunk stimulation-induced AF experimental model has the beneficial effects that an acute AF animal model is manufactured through accurately positioning and stimulating dog's vagal nerve trunk, vagal nerve plexus in blood vessels and an epicardial fat pad, so that the induction rate and the stability of the model are improved; the time of duration is increased; and the manufactured dog vagus nerve-mediated AF model has the characteristics of atrial muscle and pulmonary vein electrophysiological change characteristics similarity to paroxysmal AF patients.

Description

technical field [0001] The invention relates to the field of autonomic nerve-mediated AF (atrial fibrillation) occurrence and development mechanism and intervention research, in particular to a method for establishing an experimental model of canine vagus nerve trunk stimulation-induced atrial fibrillation Background technique [0002] In 1955, Hoff and Geddes reported that stimulation of cholinergic nerve fibers in dogs could induce atrial fibrillation with or without premature beats, and for the first time produced a model of atrial fibrillation mediated by vagus neurotransmitters in dogs. From 1959 to 1985, Allessie et al. used the dog heart Langendoff perfusion model to perfuse acetylcholine and rapidly pace the atrium, established a continuous atrial fibrillation model, and used multiple endocardial electrodes to map the atrial myoelectric activity during atrial fibrillation, confirming that After the multi-wave reentry theory proposed by Moe and Abildskov, in 1992, Sch...

Claims

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Application Information

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IPC IPC(8): A61N1/36
Inventor 侯月梅范平王红丽
Owner 侯月梅
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