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Calcium phosphate-based composite microsphere support and preparation method thereof

A technology of composite microspheres and calcium phosphate, applied in the field of preparation of biomedical materials, can solve the problems of low pore size, limited collapse resistance, limited mechanical strength, etc., and achieve moderate pore size, high collapse resistance and enhanced mechanical properties. Effect

Active Publication Date: 2013-11-20
广州智焜生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the stents made by the above-mentioned prior art generally have the problems of limited collapse resistance, limited mechanical strength, and low pore size.

Method used

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  • Calcium phosphate-based composite microsphere support and preparation method thereof

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Embodiment 1

[0038]Dissolve 0.3g of polyglycolide-lactide in 10mL of dichloromethane to obtain polyglycolide-lactide solution; 0.3g of partially crystalline calcium phosphate (PCCP) and 0.2g of anhydrous calcium hydrogen phosphate (DCPA) Disperse in polyglycolide-lactide solution to obtain solution 1; add 8mL Tween-80 to 400mL liquid paraffin to obtain solution 2; add solution 1 to solution 2 while stirring, and continue stirring at 400rpm Composite microspheres were obtained after 10 hours, washed 4 times with anhydrous ether, and then freeze-dried; 0.28 g of microspheres of 350-400 μm obtained after sieving were poured into a mold, 1 mL of deionized water was added, and after standing for 12 minutes, the cylinder was used to Apply pressure at 500kPa for 4s; after demoulding, maintain in a constant temperature and humidity chamber at 37°C and 97% humidity for 18h, soak in cold acetone at -75°C for 4h, and then freeze-dry for 50h to obtain calcium phosphate-based microsphere scaffolds.

[...

Embodiment 2

[0041] Dissolve 0.4g of polyglycolide-lactide in 10mL of dichloromethane to obtain polyglycolide-lactide solution; 0.35g of partially crystalline calcium phosphate (PCCP) and 0.25g of anhydrous calcium hydrogen phosphate (DCPA) Disperse in polyglycolide-lactide solution to obtain solution 1; add 6mL Tween-80 to 300mL liquid paraffin to obtain solution 2; add solution 1 to solution 2 while stirring, and continue stirring at 300rpm Composite microspheres were obtained after 8 hours, washed 3 times with anhydrous ether, and then freeze-dried; 0.3 g of microspheres of 300-350 μm obtained after sieving were poured into a mold, 1 mL of deionized water was added, and after standing for 15 min, the cylinder was used to Apply pressure at 800kPa for 5s; after demoulding, maintain in a constant temperature and humidity chamber at 37°C and 97% humidity for 12h, soak in cold acetone at -85°C for 5h, and then freeze-dry for 40h to obtain calcium phosphate-based microsphere scaffolds.

[004...

Embodiment 3

[0044] Dissolve 0.5g of polyglycolide-lactide in 10mL of dichloromethane to obtain polyglycolide-lactide solution; 0.275g of partially crystalline calcium phosphate (PCCP) and 0.275g of anhydrous calcium hydrogen phosphate (DCPA) Disperse in polyglycolide-lactide solution to obtain solution 1; add 30mL Tween-80 to 500mL liquid paraffin to obtain solution 2; add solution 1 to solution 2 while stirring, and continue stirring at 500rpm Composite microspheres were obtained after 8 hours, washed 5 times with anhydrous ether, and then freeze-dried; 0.35 g of microspheres of 400-450 μm obtained after sieving were poured into a mold, 1 mL of deionized water was added, and after standing for 10 min, the cylinder was used to Apply pressure at 700kPa for 6s; after demoulding, maintain in a constant temperature and humidity chamber at 37°C and 97% humidity for 24h, soak in cold acetone at -80°C for 6h, and then freeze-dry for 60h to obtain calcium phosphate-based microsphere scaffolds.

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Abstract

The invention discloses a calcium phosphate-based composite microsphere support and a preparation method thereof. The preparation method comprises the following steps of dissolving polyglycollide-lactide in dichloromethane to obtain a polyglycollide-lactide solution; dispersing crystallized calcium phosphate and anhydrous calcium hydrogen phosphate in the polyglycollide-lactide solution to obtain a solution 1; adding Tween-80 to liquid wax to obtain a solution 2: adding the solution 1 to the solution 2 under a stirring state to obtain composite microspheres; pouring the composite microspheres into a mold, adding deionized water, conserving in a constant temperature and humidity chamber after demolding; immersing in cold acetone and freeze drying to obtain the calcium phosphate-based composite microsphere support. The prepared microsphere support has a three-dimensional through pore structure with moderate pore size, and has good mechanical properties and good biocompatibility. The pore size of the support is further enlarged after polyglycollide-lactide is degraded, thereby facilitating the formation of new bones. Besides, the preparation process is simple; raw materials are easily available; cost is low and industrialized production can be easily realized.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to a calcium phosphate-based composite microsphere scaffold and a preparation method thereof. Background technique [0002] Bone is one of the most important tissues in the human body. It plays an important role in protecting internal organs, providing attachment for muscles, and producing blood cells. There are countless bone defects or incomplete limbs caused by trauma, aging, exercise, inflammation, tumors and congenital deformities in the human body. Therefore, there is a huge demand for bone repair materials. Bone repair materials can replace or repair human diseased bone tissue and achieve regenerative functions. The research and development of bone repair materials is a global issue, and it is also a very active field in biomaterial research. According to the report of the civil affairs department, there are about 15 million patients w...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/56
Inventor 魏坤许为康
Owner 广州智焜生物科技有限公司
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